解剖学报 ›› 2019, Vol. 50 ›› Issue (3): 400-404.doi: 10.16098/j.issn.0529-1356.2019.03.023

• 综述 • 上一篇    

骨髓间充质干细胞成脂成骨平衡调控研究进展

占秀文1 杨磊1,2* 郑美蓉1 汪鑫平1 许晓源1*   

  1. 1.九江学院江西省系统生物医学重点实验室, 江西 九江 332000; 2.九江学院基础学院人体解剖学教研室,江西 九江 332000
  • 收稿日期:2018-06-11 修回日期:2018-08-26 出版日期:2019-06-06 发布日期:2019-06-06
  • 通讯作者: 许晓源 E-mail:yangleigeili@163.com
  • 基金资助:
    RUNX2-miR320a-BMP6以前馈环模式调控人类成骨细胞分化的机制研究;环状RNAFGFR1/miR-6756-5p/ FASN轴向调控脂肪细胞早期分化过程机制研究;miR-604 靶向作用 MIER1 调控成骨细胞分化的机制研究

Research progress on the balance regulation of osteogenic differentiation and adipogenic differentiation in bone marrow mesenchymal stem cell

ZHAN Xiu-wen1 YANG Lei 1,2* ZHENG Mei-rong1 WANG Xin-ping1 XU Xiao-yuan 1*   

  1. 1.Key Laboratory of System BioMedicine of Jiangxi Province, Jiujiang University, Jiangxi Jiujiang 332000, China; 2.Department of Human Anatomy, Jiujiang University, Jiangxi Jiujiang 332000, China
  • Received:2018-06-11 Revised:2018-08-26 Online:2019-06-06 Published:2019-06-06
  • Contact: XU Xiao-yuan E-mail:yangleigeili@163.com

摘要:

骨质疏松症(OP)是一种全身性的骨代谢疾病,主要表现为骨量减少、骨质脆性增加、骨骼微结构退化。随着对骨质疏松症发病机制的深入研究,骨髓间充质干细胞(BMSCs)分化失衡(成骨分化减少,成脂分化增多)是引发骨质疏松症的关键。我们总结了BMSCs成脂成骨分化相关的信号通路,充分理解这些信号通路,有利于更好的阐明骨质疏松症的发病机制,为临床医生有效地治疗骨质疏松症提供帮助。

关键词: 平衡调控, 骨髓间充质干细胞, 成骨分化, 成脂分化, 信号通路

Abstract:

Osteoporosis (OP), a systemic bone metabolism disease, mainly manifested in the decrease of bone mass, the increase of bone fragility and the microstructure degeneration of the bone. Along with the in-depth research of the pathogenesis of osteoporosis, the imbalance differentiation of bone marrow mesenchymal stem cell (BMSCs) (Osteogenic differentiation decrease and adipogenic differentiation increase) is the main reason that causes osteoporosis. In this paper, we summarize the signal pathways of osteogenic differentiation and adipogenic differentiation of BMSCs. Better understand these signal pathways is conducive to elucidate and treat osteoporosis.

Key words: Balance regulation, Bone marrow mesenchymal stem cell, Osteogenic differentiation, Adipogenic differentiation, Signal pathway