解剖学报

解剖学报 ›› 2019, Vol. 50 ›› Issue (3): 369-373.doi: 10.16098/j.issn.0529-1356.2019.03.018

• 人类学 • 上一篇    下一篇

摩梭人身体铁状态与血糖升高的相关性

苏明杰 李辉*   

  1. 复旦大学生命科学学院现代人类学教育部重点实验室,上海 200438
  • 收稿日期:2018-06-05 修回日期:2018-07-16 出版日期:2019-06-06 发布日期:2019-06-06
  • 通讯作者: 李辉 E-mail:lihui.fudan@gmail.com
  • 基金资助:
    美国国家科学基金会行为与认知科学基金

Relationship between body iron and elevated blood glucose in Mosuo people

SU Ming-jie LI Hui*   

  1. Ministry of Education Key Laboratory of Contemporary Anthropology，School of Life Sciences，Fudan University，Shanghai 200438, China
  • Received:2018-06-05 Revised:2018-07-16 Online:2019-06-06 Published:2019-06-06
  • Contact: LI Hui E-mail:lihui.fudan@gmail.com
  • Supported by:
    NSF-BCS

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摘要：

目的 探讨中国云南摩梭人群生理性铁储备，贫血与血糖升高的相关性。 方法 收集云南省宁蒗县187名摩梭人血样，检测其糖化血红蛋白（HbA1c）、转铁蛋白受体（TfR）与血红蛋白水平（Hb）。逻辑回归分析摩梭人数据和中国全国性数据（CHNS）中铁状态与血糖升高的关系。 结果 与控制组相比，摩梭人缺铁而不贫血，即缺铁性红细胞生成（IDE）对应着血糖升高风险的上升（OR=2.70），这一结果与针对全国性数据的分析结果一致。 结论 相比健康人群，缺铁性贫血与非缺铁性贫血的摩梭人，缺铁而不存在贫血症状的摩梭人面临着血糖升高的风险。 摩梭人身体铁水平对其2型糖尿病的风险评估与预防具有参考意义。

关键词: 糖化血红蛋白, 贫血, 血糖升高, 逻辑回归, 干血斑转铁蛋白受体检测, 摩梭人

Abstract:

Objective To study the relationship between physiological iron reserve, anemia and elevated blood glucose in Mosuo population in Yunnan, China. Methods Blood samples were collected from 187 Mosuo people in Ninglang County, Yunnan Province, and their glycated hemoglobin (HbA1c), transferrin receptor (TfR) and hemoglobin levels (Hb) were measured. Logistic Regression analysed the relationship between iron status and elevated blood glucose in Mosuo data and Chinese national data (CHNS). Results Compared with the control group, Mosuo people were deficient in iron without anemia, ie iron deficiency erythropoiesis (IDE) corresponds to an increase in the risk of elevated blood glucose (OR=2.70), which is consistent with national data for China. The results of the analysis are consistent.  Conclusion Compared with healthy people, Mosuo people with iron deficiency anemia and non-iron deficiency anemia, Mosuo people who are deficient in iron without anemia are at risk of rising blood sugar. The body iron level of Mosuo people has reference significance for the risk and control of type 2 diabetes.

Key words: Glycated hemoglobin, Anemia, Elevated blood glucose, Logistic Regression, Dry blood spot transferrin receptor test, Mosuo