炎症反应在细胞焦亡和动脉粥样硬化之间的作用

doi:10.16098/j.issn.0529-1356.2019.04.024

摘要/Abstract

摘要：

心血管疾病是全球慢性非传染性疾病中死亡率最高的一类疾病，而动脉粥样硬化（AS）在心血管疾病的发生发展中扮演了重要的角色。炎症反应与动脉粥样硬化形成密切相关，而其又广泛参与细胞焦亡过程。核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）、适配器凋亡相关微粒蛋白（apoptosis-associated speck-like protein containing CARD，ASC）以及Caspase-1等细胞焦亡的重要功能分子均参与AS形成，细胞焦亡的过程中伴随白细胞介素等炎症介质的产生及释放，而炎症反应又可反过来促进细胞焦亡的发生发展。我们分别从炎症反应在动脉粥样硬化、细胞焦亡形成中的作用，炎症反应在这两者之间的桥梁作用等3个方面进行综述。

关键词: 炎症, 细胞焦亡, 动脉粥样硬化, 信号通路, 心血管疾病, 人

Abstract:

Cardiovascular disease is the highest mortality disease in the world’s chronic noninfectious diseases，and atherosclerosis plays an important role in the development of cardiovascular disease. Inflammation is closely related to the formation of atherosclerosis, and it is widely involved in the process of pyroptosis. The important functional molecules of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC) and Caspase-1 are involved in the formation of AS. The process of pyroptosis is accompanied by the production and release of interleukin(IL) and other inflammatory mediators, and the inflammatory reaction may in turn promote the development of pyroptosis. Therefore, the three aspects about the role of inflammation in atherosclerosis, pyroptosis, and its function between the two are reviewed in this review.

Key words: Inflammation, Pyroptosis, Atherosclerosis, Signaling pathway, Cardiovascular disease, Human

王熹芝袁佳莹张剑张宋欧刘学红. 炎症反应在细胞焦亡和动脉粥样硬化之间的作用[J]. 解剖学报, 2019, 50(4): 543-548.

WANG Xi-zhi YUAN Jia-ying ZHANG Jian ZHANG Song-ou LIU Xue-hong. Role of inflammation between pyroptosis and atherosclerosis[J]. Acta Anatomica Sinica, 2019, 50(4): 543-548.

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