Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (5): 617-621.doi: 10.16098/j.issn.0529-1356.2017.05.021

• Review • Previous Articles     Next Articles

Role of NF-E2-related factor 2 in retinal cell protection

PANG Yi-lin1 ZHANG Wei-guang2 ZHANG Yan2 HE Mei-hua 2*   

  1. 1.Peking University People’s Hospital, Beijing 100026, China; 2.Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  • Received:2016-12-28 Revised:2017-01-15 Online:2017-10-06 Published:2017-10-06
  • Contact: HE Mei-hua E-mail:zhangwg@bjmu.edu.cn

Abstract:

NF-E2-related factor 2 (Nrf2) is a redox sensitive transcription factor mediating many protective genes. The Nrf2-regulated antioxidant pathway has been found to be adaptively activated to counteract increased oxidative stress. Pharmacological induction of Nrf2 pathway has been implicated as a new therapeutic strategy to relieve cell damage. This review summarized the main findings on the protective role of Nrf2 in retinal diseases.

Key words: NF-E2-related factors 2, Retina, Oxidative stress, Retinal neuron, Retinal microvascular cell