Prenatal alcohol exposure inducing retinal teratogeny and cell apoptosis

doi:0.3969/j.issn.0529-1356.2013.03.001

Abstract

Abstract:

Objective To investigate the effect of teratogeny and cell apoptosis on retina after prenatal alcohol exposure
(PAE).Methods A total of 72 mouse models of prenatal alcohol exposure were made. HE staining and immunofluorescent labeling
were carried out to visualize the retinal pathology and cell apoptosis. Results High prenatal alcohol exposure increased the
rate of retinal malformation; The expression of positive cells in inner granular layer(INL) was costistent with ganglial cell
layer(GCL) in the retina with dose-dependency (P<0.05); TUNEL showed in the retina INL and GCL, alcohol induced thecell apoptosis
with long-range effects (P<0.05). Conclusion Retinal malformation and cell apoptosis probably are the cause of eye diseases induced
by PAE.

Key words: Prenatal alcohol exposure, Retinal cell, Development, HE staining, Immunofluorescent labelin, Mouse

LI Rui-ling ZHOU Jie WANG Qiang LIU Bin HUANG Xia MA Zhan-you DENG Jin-bo*. Prenatal alcohol exposure inducing retinal teratogeny and cell apoptosis[J]. AAS, 2013, 44(3 ): 297-303.

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