Roles of regenerating islet-derived protein family in liver diseases and liver regeneration

doi:10.16098/j.issn.0529-1356.2017.04.021

Abstract

Abstract:

Regenerating islet-derived protein (Reg) are a group of 16 kD secretory proteins and belong to the C-type lectin superfamily. Reg proteins are multi-functional molecules, which are mainly involved in regulating cell growth and proliferation in pancreas, stomach, intestine and liver, and play an important role in the development and prognosis of digestive diseases and cancers. We reviewed research progress of the complex roles of Reg family in liver diseases and liver regeneration, including Reg family-mediated signaling pathways in digestive diseases, and laid an important theoretical foundation for application of Reg family in the diagnosis, treatment of digestive diseases and promotion of liver regeneration.

Key words: Regenerating islet-derived protein, Liver disease, Liver regeneration

WANG Gai-ping CHEN Meng ZHAO Cong-cong CHEN Sha-sha XU Cun-shuan. Roles of regenerating islet-derived protein family in liver diseases and liver regeneration[J]. Acta Anatomica Sinica, 2017, 48(4): 488-492.

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