Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

doi:10.16098/j.issn.0529-1356.2017.06.023

Abstract

Abstract:

Liver sinusoidal endothelial cells (LSECs) are gossamer-thin cells that line the hepatic sinusoid and they are perforated with pores called fenestrations clustered in sieve plates. There is growing evidence that fenestrations may work as a permselective ultrafiltration installation which is important for the hepatic to uptake substrates, particularly metabolism of lipoproteins. Abnormal fenestratel structure had been considered as a vital factor to liver lipid metabolism disorders. This review mainly focused on the relationship between ultrastructure of the fenestration, the fenestrated mechanism, the regulation factor of fenestration, and hepatic steatosis.

Key words: Hepatic steatosis, Liver sinusoidal endothelial cell, Fenestration, Lipid metabolism

WANG Qiao-zhi FAN Jing ZHANG Wei-guang. Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis[J]. Acta Anatomica Sinica, 2017, 48(6): 766-770.

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