Advances in the effects and mechanisms of hydrogen on ischemia-reperfusion injury in diseases and organ transplantation

doi:10.16098/j.issn.0529-1356.2018.03.023

Abstract

Abstract:

Ischemiareperfusion (I/R) injury is a crucial pathophysiologic process in the development of various diseases or during organ transplantation. Hydrogen has been widely researched as a potential antioxidant in ischemia-reperfusion models of multiple diseases and organ transplantation. Herein, the authors review the current literature regarding the effects of hydrogen on ischemia-reperfusion injury and organ transplantation. Existing data on the effects and mechanisms of hydrogen on ischemia-reperfusion injury and organ transplantation are specifically reviewed and coupled with further suggestions for future work. In general, a substantial body of experimental evidence suggests that hydrogen significantly has a therapeutic effect on ischemia-reperfusion injury in models of multiple diseases and organ transplantation by inhibiting inflammatory response, oxidative stress and apoptosis through several underlying mechanisms. On this basis, further animal experiments and preliminary human clinical trial regarding the effects of hydrogen on ischemiareperfusion injury are need to be conducted for the early use of hydrogen as a drug in the clinic.

Key words: Hydrogen, Ischemia/reperfusion injury, Organ transplantation

HUANG Jun-long LIU Wen-wu SUN Xue-jun. Advances in the effects and mechanisms of hydrogen on ischemia-reperfusion injury in diseases and organ transplantation[J]. Acta Anatomica Sinica, 2018, 49(3): 406-411.

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