Objective To measure the handgrip strength of Tibetan adults in Lhasa, and to explore its changing trends and characteristics. This provides a basis for the determination of the Tibetan grip strength reference value.  Methods China (Xiangshan) CAMRY EH101 electronic gripper measured the grip strength of healthy Tibetan adults aged 20-70 in Chengguan District of Lhasa City. There were a total of 760 respondents (310 males and 450 females). After stratifying them by age and gender, they analyzed their changes.  Results The average handgrip strength of male Tibetan adults aged 20-69 in Lhasa was (34.50±8.36) kg. The median male grip strength was 35 kg. The grip strength reached the peak (39.87 kg) in the 20- group. From the 40- group, the grip strength value decreased with age. The average grip strength of female Tibetan adults was (21.54±5.73) kg. The median female grip strength is 22 kg. There was no significant difference in grip strength between the ages of 20- and 40-.The grip strength reached a peak (23.41 kg) in the 40- group. From the 50- group, the grip strength value decreased with age. The average grip strength of Tibetan adults in Lhasa was (26.83±9.41) kg, and the median grip strength was 26 kg. The average grip strength of males in the same age group was higher than that of females. The hand grip strength decreased with increasing altitude (P<0.05).  Conclusion There is a difference in gender and age in hand grip, and it is also affected by altitude.