Coronin, a protein has a coronal-like pattern and locates below the cell membrane. Owing to its particular structure, coronin plays a key role in embryonic development and epithelial cell migration via its binding to microfilaments. Recently, proteins in coronin family were demonstrated that they could regulate the proliferation and migration of tumor cells through a series of molecular mechanisms, and there was a positive relationship between its abnormal expression and prognosis in the clinical patients. Therefore, its function and role in the progress of tumorigenesis is a hot topic in the current field of tumor research. In this paper, we made a comprehensive description of its molecular structural features, summarized its different roles in tumors, and predict its potential therapeutic prospects in the future.