Multi-index analysis of regional brain activity in patients with Alzheimer’s disease during resting state

doi:10.16098/j.issn.0529-1356.2023.01.011

Abstract

Abstract:

Objective To investigate the spontaneous neural activity in the brain of patients with Alzheimer’s disease (AD) used 3 indicators of resting state-functional magnetic resonance (rs-fMRI) amplitude of low frequency fluctuation (ALFF), fractional amplitude of low frequency fluctuation (fALFF) and percentage amplitude fluctuation (PerAF). MethodsTotally 36 clinically diagnosed AD patients and 40 healthy volunteers were scanned by fMRI in resting state respectively. ALFF, fALFF and PerAF were used to calculate and compare the changes of brain regions between the two groups. Results Compared with the normal control group, mALFF value in AD group increased significantly in bilateral caudate nucleus, medial frontal gyrus, superior frontal gyrus, gyrus rectus, anterior cingulate gyrus, olfactive cortex, left middle frontal gyrus and inferior frontal gyrus (P<0.05). mALFF values decreased significantly in the right middle temporal gyrus, inferior temporal gyrus, inferior occipital gyrus, middle occipital gyrus, bilateral calcarine, cuneus, lingual gyrus, superior occipital gyrus，vermis, precuneus and other regions (P<0.05). In AD group, mfALFF value of right inferior temporal gyrus, anterior cerebellar lobe, fusiform gyrus, left superior frontal gyrus, medial frontal gyrus, middle frontal gyrus, inferior frontal gyrus, gyrus rectus and anterior cingulate gyrus increased significantly (P<0.05); mfALFF values decreased significantly in bilateral lingual gyrus, left calcarine, cuneus, superior occipital gyrus, middle occipital gyrus and vermis (P<0.05). In AD group, mPerAF value incr eased significantly in bilateral gyrus rectus, anterior cingulate gyrus, medial frontal gyrus, left superior frontal gyrus, caudate nucleus, middle frontal gyrus, inferior frontal gyrus, olfactive cortex and insula (P<0.05); mPerAF values decreased significantly in bilateral calcarine, cuneus, superior occipital gyrus, lingual gyrus, precuneus, left fusiform gyrus, inferior occipital gyrus, right superior parietal lobule, angular gyrus, middle temporal gyrus, inferior temporal gyrus and middle occipital gyrus (P<0.05). Conclusion The default mode network (DMN) and visual network of AD patients are characterized by abnormal brain activity, with the most significant neural activity in the prefrontal cortex and visual cortex.

Key words:

Alzheimer’s disease, Amplitude of low frequency fluctuation, Fractional amplitude of low frequency fluctuation, Percentage amplitude fluctuation, Resting state-functional magnetic resonance, Human

CLC Number:

R455.2

XU Lin LIU Xiao-li CHEN Zheng-zhen WEN Cai-yun LI Chang-sheng LI Ru-hua CHEN Dai-qian CHEN Cheng-chun. Multi-index analysis of regional brain activity in patients with Alzheimer’s disease during resting state[J]. Acta Anatomica Sinica, 2023, 54(1): 75-81.

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