Distribution of gonadotropin releasing hormone receptor in cervicothoracic ganglion of female goats

doi:10.3969/j.issn.0529-1356.2014.02.004

Abstract

Abstract:

Objective To explore whether cervicothoracic ganglion has the condition by which gonadotropin releasing hormon(GnRH) can exert its function. Methods Immunohistochemical SP method was adopted to observe the distribution of GnRH receptor (GnRHR) in cervicothoracic ganglion of female goats. Results The results showed that, all the neurons in cervicothoracic ganglion responded positively to GnRHR. The membrane of neurons and the granular material in cytoplasm were strong positive. The neuronal nucleus was negative to GnRHR while neurites and satellite cells showed medium positive. Image analysis showed a significant difference of GnRHR expression between neurons and non-neurons (P＜0.01).Conclusion The results indicate that neurons in cervicothoracic ganglion are the main target cells of GnRH, and cervicothoracic ganglion has the condition by which GnRH can exert its function, which implies GnRH may regulate the function of heart and lung through the GnRHR distributed in cervicothoracic ganglion. Thus，the GnRHR existing in these neurons may be a “transfer station” for GnRH to coordinate heart and lung activity through endocrine and autonomic nerve pattern.

DONG Wei LI Qiang XU Yong-ping* JIN Xiu-fang CHEN Wen-dong GUO Xiao. Distribution of gonadotropin releasing hormone receptor in cervicothoracic ganglion of female goats[J]. AAS, 2014, (2): 166-170.

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