解剖学报 ›› 2014, Vol. 45 ›› Issue (6): 865-869.doi: 10.3969/j.issn.0529-1356.2014.05.024

• 综述 • 上一篇    

整合素相互作用蛋白Kindlin家族的生物学功能研究进展

杨玫1,2陈曦3 张水文1 张宏权2*   

  1. 1. 北京军区总医院生殖医学中心,北京 100700; 2. 北京大学医学部基础医学院组织学与胚胎学教研室,北京 100191; 3. 北京大学人民医院生殖医学中心,北京 100044
  • 收稿日期:2014-02-21 修回日期:2014-04-23 出版日期:2012-12-06 发布日期:2014-12-06
  • 通讯作者: 张宏权 E-mail:hongquan.zhang@bjmu.edu.cn
  • 基金资助:

    整合素结合性信号分子Kindlin-1与多种重要蛋白质相互作用:结构解析、生物学功能和作用机制研究

Research progress of biological function in integrin-interacting protein kindlin family

YANG Mei1,2 CHEN Xi3 ZHANG Shui-wen1 ZHANG Hong-quan2*   

  1. 1. Center for Reproductive Medicine, Beijing Military General Hospital, Beijing 100700, China; 2. Department of Histology and Embryology, School of Basic Medicine, Peking University, Beijing 100191, China; 3. Center for Reproductive Medicine, Peking University Second Hospital, Beijing 100044, China
  • Received:2014-02-21 Revised:2014-04-23 Online:2012-12-06 Published:2014-12-06
  • Contact: ZHANG Hong-quan E-mail:hongquan.zhang@bjmu.edu.cn

摘要:

整合素相互作用蛋白Kindlin是一种新型的黏着斑蛋白,是进化上高度保守的含有FERM结构域的蛋白家族,目前已知有3个家族成员Kindlin-1、Kindlin-2和Kindlin-3。近年来研究表明,Kindlin家族不仅与整合素活化和多种遗传性疾病有关,而且作为重要的信号分子参与了肿瘤的发生发展过程。我们将从Kindlin的结构特征、组织分布及生物学功能的研究进展作一综述。

关键词: Kindlin家族, 整合素, 生物学功能

Abstract:

Integrin-interacting protein kindlin is a novel family of focal adhesion proteins consisting of three members, Kindlin-1, Kindlin-2 and Kindlin-3. Kindlins are highly conserved and belong to FERM-containing proteins. Present studies have showed there is a close relationship between Kindlin family and integrin activation and genetic diseases. In addition, Kindlin family is also a critical mediator for tumorigenesis. We review structural features, distribution and progress of biological functions of kindlin family in this paper.

Key words: Kindlin family, Integrin, Biological function