细胞力学微环境中Piezo1下游信号通路的研究进展

doi:10.16098/j.issn.0529-1356.2025.01.016

解剖学报 ›› 2025, Vol. 56 ›› Issue (1): 120-126.doi: 10.16098/j.issn.0529-1356.2025.01.016

• 综述 • 上一篇

细胞力学微环境中Piezo1下游信号通路的研究进展

韩卓远¹彭慧²翟效月³符园园^3*

1.中国医科大学第一临床学院，沈阳110801; 2.中国医科大学附属盛京医院肾脏内科，沈阳110004; 3.中国医科大学基础医学院组织学与胚胎学教研室，沈阳110122

收稿日期:2023-11-30 修回日期:2024-02-05 出版日期:2025-02-06 发布日期:2025-02-06
通讯作者: 符园园 E-mail:yyfu@cmu.edu.cn
基金资助:
辽宁省自然科学基金

Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment

HAN Zhuo-yuan¹ PENG Hui² ZHAI Xiao-yue³ FU Yuan-yuan^3*

1.The First School of Clinical Medicine, China Medical University, Shenyang 110801;
2.Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang 110004, China;
3.Department of Histology and Embryology, School of Basic Medical Sciences, China Medical University, Shenyang 110122, China

Received:2023-11-30 Revised:2024-02-05 Online:2025-02-06 Published:2025-02-06
Contact: FU Yuan-yuan E-mail:yyfu@cmu.edu.cn

摘要/Abstract

摘要：

细胞所处的微环境存在多种力学信号，具有时间和空间变化性，共同调控细胞增殖、分化和迁移等组织学过程。Piezo1是一种机械敏感性阳离子通道，作为力传感器响应细胞微环境的变化，将信号传递给下游通路，参与多种生命活动。本文中我们对Piezo1的工作原理、相关信号通路和活性调节进行了综述，以期归纳Piezo1调控的下游信号通路，为阻抑或延缓相关疾病提供理论依据。

关键词:

Piezo1, 机械力, 细胞外基质

Abstract:

There are a variety of mechanical signals in the microenvironment of cells, which have temporal and spatial variability, which jointly regulate the histological processes such as cell proliferation, differentiation and migration. Piezo1 is a mechanically sensitive cationic channel. As a force sensor, it transmits signals to downstream pathways and participates in a variety of life activities in response to changes in the cell microenvironment. In this paper, the common signal pathways of Piezo1 were reviewed in order to identify the downstream signaling pathways regulated by Piezo1, thereby providing theoretical basis for inhibiting or delaying related diseases.

Key words:

, Piezo1, Mechanical force, Extracellular matrix

中图分类号:

R34

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韩卓远彭慧翟效月符园园. 细胞力学微环境中Piezo1下游信号通路的研究进展[J]. 解剖学报, 2025, 56(1): 120-126.

HAN Zhuo-yuan PENG Hui ZHAI Xiao-yue FU Yuan-yuan. Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment[J]. Acta Anatomica Sinica, 2025, 56(1): 120-126.

参考文献

［1］Douguet D, Patel A, Xu A, et al. Piezo ion channels in cardiovascular mechanobiology［J］. Trends Pharmacol Sci,2019,40(12):956-970.

［2］Zong B, Yu F, Zhang X, et al. Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system［J］. Ageing Res Rev,2023,90:102026.

［3］Li X, Hu J, Zhao X, et al. Piezo channels in the urinary system［J］. Exp Mol Med,2022,54(6):697-710.

［4］Tang H, Zeng R, He E, et al. Piezo-type mechanosensitive ion channel component 1 (piezo1): a promising therapeutic target and its modulators［J］. J Med Chem,2022,65(9):6441-6453.

［5］Min ZY, Munire·Aili, Zheng YH, et al. Mechanism and characteristics of mechanical microenvironment of extracellular matrix and intercellular interaction［J］. Chinese Journal of Tissue Engineering Research,2022,26(25): 4034-4045.(in Chinese)

闵子洋, 穆妮热·艾力, 郑耘昊, 等. 细胞外基质力学微环境与细胞间相互作用的机制与特征［J］. 中国组织工程研究, 2022, 26(25): 4034-4045.

［6］Sun Q, Wei Q, Zhao CS. How do the cells sense and respond to the microenvironment mechanics［J］. Chin Sci Bull,2021,66 (18): 2303-2311.

［7］Matellan C, Del Río Hernández AE. Engineering the cellular mechanical microenvironment-from bulk mechanics to the nanoscale［J］. J Cell Sci,2019,132(9):jcs229013.

［8］Dalghi MG, Clayton DR, Ruiz WG, et al. Expression and distribution of PIEZO1 in the mouse urinary tract［J］. Am J Physiol Renal physiol,2019, 317(2):F303-F321.

［9］Wang Y, Xiao B. The mechanosensitive Piezo1 channel: structural features and molecular bases underlying its ion permeation and mechanotransduction［J］. J Physiol, 2018, 596(6):969-978.

［10］Zhao Q, Zhou H, Chi S, et al. Structure and mechanogating mechanism of the Piezo1 channel［J］. Nature,2018,554(7693):487-492.

［11］Zhao Q, Wu K, Geng J, et al. Ion permeation and mechanotransduction mechanisms of mechanosensitive Piezo channels［J］. Neuron,2016,89(6):1248-1263.

［12］Jiang Y, Yang X, Jiang J, et al. Structural designs and mechanogating mechanisms of the mechanosensitive Piezo channels［J］. Trends Biochem Sci,2021,46(6):472-488.

［13］Saotome K, Murthy SE, Kefauver JM, et al. Structure of the mechanically activated ion channel Piezo1［J］. Nature,2018,554(7693):481-486.

［14］Zhao Q, Zhou H, Li X, et al. The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism［J］. FEBS J,2019,286(13):2461-2470.

［15］Lewis AH, Grandl J. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension［J］. Elife,2015,4:e12088.

［16］Lai A, Cox CD, Chandra Sekar N, et al. Mechanosensing by Piezo1 and its implications for physiology and various pathologies［J］. Biol Rev Camb Philos Soc,2022, 97(2):604-614.

［17］Sasaki F, Hayashi M, Mouri Y, et al. Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes［J］. Biochem Biophys Res Commun,2020,521(3):806-813.

［18］Song J, Liu L, Lv L, et al. Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells［J］. Cell Biol Int,2020,44(7):1491-1502.

［19］Lai A, Chen YC, Cox CD, et al. Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo1 in human aortic endothelial cells［J］. J Cell Physiol,2021,236(4):2976-2987.

［20］Porto Ribeiro T, Barbeau S, Baudrimont I, et al. Piezo1 channel activation reverses pulmonary artery vasoconstriction in an early rat model of pulmonary hypertension: the role of Ca²⁺ influx and Akt-eNOS pathway［J］. Cells,2022,11(15):2349.

［21］Mousawi F, Peng H, Li J, et al. Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling［J］. Stem Cells,2020,38(3):410-421.

［22］Zheng Q, Zou Y, Teng P, et al. Mechanosensitive channel Piezo1 senses shear force to induce KLF2/4 expression via CaMKⅡ/MEKK3/ERK5 axis in endothelial cells［J］. Cells,2022,11(14):2191.

［23］Liu H, Bian W, Yang D, et al. Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways［J］. Life Sci,2021,264:118667.

［24］Atcha H, Meli VS, Davis CT, et al. Crosstalk between CD11b and Piezo1 mediates macrophage responses to mechanical cues［J］. Front Immunol,2021,12:689397.

［25］Chen X, Wanggou S, Bodalia A, et al. A feedforward mechanism mediated by mechanosensitive ion channel piezo1 and tissue mechanics promotes glioma aggression［J］. Neuron,2018,100(4):799-815.e7.

［26］Guo XW, Zhang H, Huang JQ, et al. Piezo1 ion channel mediates ionizing radiation-induced pulmonary endothelial cell ferroptosis via Ca²⁺/Calpain/VE-cadherin signaling［J］. Front Mol Biosci,2021,8:725274.

［27］Friedrich EE, Hong Z, Xiong S, et al. Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions［J］. Proc Natl Acad Sci USA,2019,116(26):12980-12985.

［28］Zhang Y, Jiang L, Huang T, et al. Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats［J］. Respir Res,2021,22(1):250.

［29］Acheta J, Bhatia U, Haley J, et al. Piezo channels contribute to the regulation of myelination in Schwann cells［J］. Glia,2022,70(12):2276-2289.

［30］Xiong Y, Dong L, Bai Y, et al. Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis［J］. Channels (Austin),2022,16(1):159-166.

［31］Yang Y, Wang D, Zhang C, et al. Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation［J］. Hum Cell,2022,35(1):51-62.

［32］Zhou LL, Liu Zh, Hong XK, et al. Mechanosensitive ion channel Piezo1 promotes glioma invasion and aggression by regulating Yes-associated protein［J］. Chinese Journal of Neuromedicine,2021,20(2):117-125.(in Chinese)

周丽丽, 刘振, 洪旋科, 等. 机械敏感离子通道PIEZO1通过YAP促进胶质瘤侵袭进展的研究［J］. 中华神经医学杂志,2021,20(2):117-125.

［33］Fu Y, Wan P, Zhang J, et al. Targeting mechanosensitive Piezo1 alleviated renal fibrosis through p38 MAPK-YAP pathway［J］. Front Cell Dev Biol,2021,9:741060.

［34］Wu J, Chen Y, Liao Z, et al. Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration［J］. Mol Ther, 2022,30（10）：3241-3256.

［35］Sun Y, Leng P, Song M, et al. Zhang H. Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca²⁺/NF-κB pathway［J］. Int Immunopharmacol,2020,85:106681.

［36］Xing Y, Yang B, He Y, et al. Effects of mechanosensitive ion channel Piezo1 on proliferation and osteogenic differentiation of human dental follicle cells［J］. Ann Anat,2022,239:151847.

［37］Caolo V, Debant M, Endesh N, et al. Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells［J］. Elife,2020,9:e50684.

［38］Wang L, Wang X, Ji N, et al. ［Mechanisms of the mechanically activated ion channel Piezo1 protein in mediating osteogenic differentiation of periodontal ligament stem cells via the Notch signaling pathway］［J］. Hua Xi Kou Qiang Yi Xue Za Zhi,2020,38(6):628-636.

［39］Qi Y, Andolfi L, Frattini F, et al. Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons［J］. Nat Commun,2015,6:8512.

［40］Narayanan P, Hütte M, Kudryasheva G, et al. Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons［J］. Elife,2018,7:e32346.

［41］Gnanasambandam R, Ghatak C, Yasmann A, et al. GsMTx4: mechanism of inhibiting mechanosensitive ion channels［J］. Biophys J,2017,112(1):31-45.

［42］Nickolls AR, O’Brien GS, Shnayder S, et al. Reevaluation of Piezo1 as a gut RNA sensor［J］. Elife,2022,11:e83346.

［43］Matute JD, Duan J, Blumberg RS. Microbial RNAs Pressure Piezo1 to Respond［J］. Cell,2020,182(3):542-544.

［44］Syeda R, Xu J, Dubin AE, et al. Chemical activation of the mechanotransduction channel Piezo1［J］. Elife,2015,4:e07369.

［45］Evans EL, Cuthbertson K, Endesh N, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation［J］. Br J Pharmacol,2018,175(10):1744-1759.

细胞力学微环境中Piezo1下游信号通路的研究进展

Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment

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