同源盒蛋白B9及其翻译后修饰在肿瘤发生发展中的作用

doi:10.16098/j.issn.0529-1356.2025.01.007

解剖学报 ›› 2025, Vol. 56 ›› Issue (1): 50-57.doi: 10.16098/j.issn.0529-1356.2025.01.007

同源盒蛋白B9及其翻译后修饰在肿瘤发生发展中的作用

何俊铭^1,2于淼²张宏权^2*战军^2*

1.北京大学医学部2019级基础医学八年制，北京100083; 2.北京大学医学部人体解剖学与组织学胚胎学系，癌症发生与转化研究教育部重点实验室，北京大学国际癌症研究院，北京100083

收稿日期:2024-06-13 修回日期:2024-07-09 出版日期:2025-02-06 发布日期:2025-02-06
通讯作者: 张宏权战军 E-mail:zhanjun@bjmu.edu.cn
基金资助:
国家自然科学基金面上项目;北京市自然科学基金面上项目

Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor

HE Jun-ming^1,2 YU Miao²ZHANG Hong-quan^2* ZHAN Jun^2*

1.Grade 2019, Basic Medicine Eight-Year, Peking University Health Science Center, Beijing 100083, China;
2.Department of Human Anatomy, Histology and Embryology, Peking University Health Science Center, MOE Key Laboratory of Carcinogenesis and Translational Research, Peking University International Cancer Institute, Beijing 100083, China

Received:2024-06-13 Revised:2024-07-09 Online:2025-02-06 Published:2025-02-06
Contact: ZHANG Hong-quan ZHAN Jun E-mail:zhanjun@bjmu.edu.cn

摘要/Abstract

摘要：

同源盒蛋白（HOX）基因编码了一组进化上高度保守的蛋白，且与胚胎的轴向发育密切相关，HOX基因的缺失或异常表达引起的体节发育异常已在果蝇及小鼠等动物中被观察到。而后续研究发现，HOX基因家族编码的蛋白质也参与肿瘤发生发展的调控。以往作者对HOX全家族进行了综述，随着研究的深入，我们关注到该家族成员HOXB9的重要作用，并在该蛋白翻译后修饰的研究中取得了新的进展。我们以HOXB9为主线，对该分子参与的肿瘤相关信号通路以及该分子翻译后修饰对肿瘤进展的调节作用进行了总结，并对未来可能的研究方向做出展望。

关键词: 同源盒蛋白B9, 翻译后修饰, 肿瘤

Abstract:

Homeobox(HOX) genes encode a group of proteins that are highly conserved and closely related to the axial differentiation of embryos. The disorder of segmental development caused by HOX genes deficiency or abnormal expression has been observed in drosophila and mice. However, subsequent studies have found that proteins encoded by the HOX gene family are also involved in the regulation of tumor genesis and development. The roles of the whole HOX family had been reviewed by the author in the past, and through the in-depth researches, the author paid attention to the pivotal role of HOXB9 and made new progress in the study of post-translational modifications of this protein. Taking HOXB9 as a clue, this review summarizes the tumor-related signaling pathways and the modulating effects of post-translational modification of HOXB9 on tumor progression, as well as the possible research directions in the future.

Key words: Homeobox B9, Post-translational modifications, Tumor

中图分类号:

R730.23

何俊铭于淼张宏权战军. 同源盒蛋白B9及其翻译后修饰在肿瘤发生发展中的作用[J]. 解剖学报, 2025, 56(1): 50-57.

HE Jun-ming YU Miao ZHANG Hong-quan ZHAN Jun. Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor[J]. Acta Anatomica Sinica, 2025, 56(1): 50-57.

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同源盒蛋白B9及其翻译后修饰在肿瘤发生发展中的作用

Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor

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