Current status of neurogenesis in neurotoxin-induced animal models for Parkinson’s disease

doi:10.16098/j.issn.0529-1356.2017.05.020

Abstract

Abstract:

The animal model of Parkinson’s disease (PD) plays an important role in understanding its etiology, pathogenesis and detection of new treatment regimens. The discovery of endogenous neurogenesis in the adult mammalian brain provides a new direction for the therapy of neurodegenerative diseases, such as PD, based on cellular approaches. Although a lot of attention has been focused on neurotoxininduced endogenous neurogenesis in the brain of animal models for PD, it remains controversial whether neural stem cells migrate to the damaged brain region and promote the repopulation of reduced dopaminergic neurons in adult neurotoxic injured animals. In this paper, we review various literatures on neurogenesis in neurotoxininduced animal models for PD, aiming to deepen the understanding of the role of neurogenesis in neurotoxicity-induced animal models for PD.

Key words: Parkinson’s disease, Neurotoxin, Neural stem cell, Neurogenesis, Animal model

XIE Ming-qi CHEN Zhi-chi WANG Tong-tong ZHOU Xiang HUANG Hou-ju QI Shuang-shuang LIAO Min SUN Chen-you. Current status of neurogenesis in neurotoxin-induced animal models for Parkinson’s disease[J]. Acta Anatomica Sinica, 2017, 48(5): 610-616.

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