Role of mammalian target of rapamycin in brain physiology and pathology

doi:10.16098/j.issn.0529-1356.2018.05.022

Abstract

Abstract:

Target of rapamycin（TOR）and its mammalian ortholog mammalian target of rapamycin(mTOR) have been discovered in an effort to understand the mechanisms of action of the immunosuppressant drug rapamycin. mTOR is a serine/threonine kinase existed in two functionally distinct complexes, mTORC1 and mTORC2, which control many basic cellular functions such as protein synthesis, energy metabolism, cell size, lipid metabolism, autophagy, mitochondria and lysosome biogenesis. In addition, mTOR-controlled signaling pathways regulate many integrated physiological functions of the nervous system including neuronal development, synaptic plasticity, memory storage, and cognition. Thus it is not surprising that deregulation of mTOR signaling may involve in many neurological and psychiatric disorders. Preclinical and preliminary clinical studies indicate that inhibition of mTORC1 can be beneficial for some pathological conditions such as epilepsy, cognitive impairment, and brain tumors, while a direct or indirect s timulation of mTORC1 can be beneficial for other pathologies such as depression or axonal growth and regeneration.

Key words: Mammalian target of rapamycin, Nervous system disease, Psychiatric disorders, Rapamycin

ZHOU Xiang FU Wei-da CHEN Zhi-chi WANG Tong-tong YE Xing ZHOU Peng CUI Huai-rui SUN Chen-you. Role of mammalian target of rapamycin in brain physiology and pathology[J]. Acta Anatomica Sinica, 2018, 49(5): 688-694.

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