Research progress on the balance regulation of osteogenic differentiation and adipogenic differentiation in bone marrow mesenchymal stem cell

doi:10.16098/j.issn.0529-1356.2019.03.023

Abstract

Abstract:

Osteoporosis (OP), a systemic bone metabolism disease, mainly manifested in the decrease of bone mass, the increase of bone fragility and the microstructure degeneration of the bone. Along with the in-depth research of the pathogenesis of osteoporosis, the imbalance differentiation of bone marrow mesenchymal stem cell (BMSCs) (Osteogenic differentiation decrease and adipogenic differentiation increase) is the main reason that causes osteoporosis. In this paper, we summarize the signal pathways of osteogenic differentiation and adipogenic differentiation of BMSCs. Better understand these signal pathways is conducive to elucidate and treat osteoporosis.

Key words: Balance regulation, Bone marrow mesenchymal stem cell, Osteogenic differentiation, Adipogenic differentiation, Signal pathway

ZHAN Xiu-wen YANG Lei ZHENG Mei-rong WANG Xin-ping XU Xiao-yuan. Research progress on the balance regulation of osteogenic differentiation and adipogenic differentiation in bone marrow mesenchymal stem cell[J]. Acta Anatomica Sinica, 2019, 50(3): 400-404.

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