Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor

doi:10.16098/j.issn.0529-1356.2025.01.007

Abstract

Abstract:

Homeobox(HOX) genes encode a group of proteins that are highly conserved and closely related to the axial differentiation of embryos. The disorder of segmental development caused by HOX genes deficiency or abnormal expression has been observed in drosophila and mice. However, subsequent studies have found that proteins encoded by the HOX gene family are also involved in the regulation of tumor genesis and development. The roles of the whole HOX family had been reviewed by the author in the past, and through the in-depth researches, the author paid attention to the pivotal role of HOXB9 and made new progress in the study of post-translational modifications of this protein. Taking HOXB9 as a clue, this review summarizes the tumor-related signaling pathways and the modulating effects of post-translational modification of HOXB9 on tumor progression, as well as the possible research directions in the future.

Key words: Homeobox B9, Post-translational modifications, Tumor

CLC Number:

R730.23

HE Jun-ming YU Miao ZHANG Hong-quan ZHAN Jun. Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor[J]. Acta Anatomica Sinica, 2025, 56(1): 50-57.

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