Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment

doi:10.16098/j.issn.0529-1356.2025.01.016

Abstract

Abstract:

There are a variety of mechanical signals in the microenvironment of cells, which have temporal and spatial variability, which jointly regulate the histological processes such as cell proliferation, differentiation and migration. Piezo1 is a mechanically sensitive cationic channel. As a force sensor, it transmits signals to downstream pathways and participates in a variety of life activities in response to changes in the cell microenvironment. In this paper, the common signal pathways of Piezo1 were reviewed in order to identify the downstream signaling pathways regulated by Piezo1, thereby providing theoretical basis for inhibiting or delaying related diseases.

Key words:

, Piezo1, Mechanical force, Extracellular matrix

CLC Number:

R34

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HAN Zhuo-yuan PENG Hui ZHAI Xiao-yue FU Yuan-yuan. Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment[J]. Acta Anatomica Sinica, 2025, 56(1): 120-126.

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