AAS ›› 2013, Vol. 44 ›› Issue (3 ): 437-440.doi: 10.3969/j.issn.0529-1356.2013.03.029

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Therapeutic research on triple negative breast cancer stem cell mammospheres

ZHAO Le LIANG Chen2  LI Qian2  PEI Xiao-hua 3*   

  1. 1. 2011 Graduate student, Surgery of Chinese Medicine; 2. 2010 Graduate Student, Surgery of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; 3. Department of Science and Education, the Third Affiliated Hospital of Beijing University of Chinese Medicine, Bejing  100029, China
  • Received:2012-12-14 Revised:2013-01-09 Online:2013-06-06 Published:2013-07-16

Abstract:

Triple negative breast cancer(TNBC)is characterized by estrogen receptor(ER) negative, progesteronereceptor(PR)
negative, and human epidermal growth factorreceptor-2(HER-2) negative histochemical staining. TNBC has the features of high
malignant degree, strong invasion, prone to distant metastasis and poor prognosis. The endocrine therapy and targeted therapy
are generally not satisfied. Finding a effective treatment is a key point in clinical research. Recent studies have shown that
occur rence and development progress of TNBC may be related to breast cancer stem cells. Mammosphere culture is a very good
method of collection of breast cancer stem cells, and is used very widely in stem cells of TNBC.

Key words: Triple negative breast cancer, Breast cancer stem cells, Mammospheres.