Fluctuating asymmetry of digit length in breast cancer patients

doi:10.3969/j.issn.0529-1356.2013.01.027

Abstract

Abstract:

Objective To study the fluctuating asymmetry (FA) of digit length in breast cancer patients in women from Ningxia Han nationality. Methods Using anthropometry, digit length of both hands of 256 individuals (controls:128; breast cancers:128)were studied. The FA of digit length was calculated and the mean value with compared between breast cancer and control groups. The relationship between the FA of digit length and the age of control and breast cancer groups were also analyzed. Results The results showed the trend of the FA in both group as follows: 2FA＞4FA＞3FA＞5FA. The mean values of each FA were higher in breast cancers than those in the controls, and there were significant differences in 2FA(P<0.01), 4FA(P<0.05),5FA(P<0.05), CFA(P<0.05) between them; There was a significant difference in|L-R|≥0.04 on distribution of 2FA between two groups（P<0.05）. It showed a negative relation between 2FA and the age at presentation of breast cancers (P<0.001). Conclusion FA, especially 2FA may be one of the important indirect early diagnosis reference marker for breast cancer.

Key words: Ningxia, Han, Digit length, Fluctuating asymmetry (FA), Breast cancer, Anthropometry, Female

CLC Number:

Q983

LU Hong,HUO Zheng-hao*,SHI Zhi-yun,DANG Jie,JIAO Hai-yan,ZHONG Hui-jun,Gao ping. Fluctuating asymmetry of digit length in breast cancer patients[J]. AAS, 2013, 44(1 ): 140-143.

References

［1］ Palmer AR, Strobeck C. Fluctuating asymmetry analysis revisited. In: Polal

M, ed. Development Stability: Causes and Consequences［M］. New York: Oxford University Press,2003:279-319.

［2］ Larry JL, Christian PK. The genetics and evolution of fluctuating asymmetry ［J］. Annu Rev Ecol Syst,2005,36:1-21

［3］ Avrilets S. A quantitative-genetic model for selection on developmental noise［J］. Evolution,1994,48(5):1478-1486.

［4］ Bramon E, Walshe M, McDonald C, et al.Dermatoglyphics and Schizophrenia：a meta-analysis and investigation of the impact of ovstetric complications upon a-b ridge count［J］.Schizophr Res,2005,75(2-3):399-404.

［5］ Natekar PE, DeSouza FM. Fluctuating asymmetry in dermatoglyphics of carcinoma of breast ［J］. Indian J Hum Genet, 2006,12 (2) :762-811.

［6］ Renee CF, Leigh WS, James MC, et al. Are body fluctuating asymmetry and the ratio of 2nd to 4th digit length reliable predictors of semen quality ［J］ ? Hum Reprod,2003,18(4):808-812.

［7］ Martin SM, Manning JT. Fluctuating asymmetry, relative digit length, and depression in men［J］.Evol Hum Behav,1999,20(3):203-214.

［8］ Manning JT. Digit Ratio: A Pointer to Fertility, Behavior, and Health［M］. London: Rutgers Univ Press, 2002:1-141.

［9］ Richard H.Introduction: fetal origins of postnatal health and disease ［J］.Early Hum Devel,2005,81(9):721-722.

［10］ Shattuck ED, Mcclure M, Simard J, et al. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibilitygene［J］. JAMA,1995,273 (7) :5352-541.

［11］ Lu H, Huo ZhH, Gao P,et al.Fluctuating asymmetry of dermatoglyphy in breast cancer patients［J］. Acta Anatomica Sinica, 2009,40(1):37-40(in Chinese)

陆宏，霍正浩，高平，等.乳腺癌患者数量皮纹学特征的波动性不对称［J］.解剖学报，2009,40(1):37-40.

［12］ Leena HC，Sonia DA. Fetal origins of breast cancer［J］.Sci Direct,2006,9,17:340-345.

［13］ Lu H, Huo ZhH, Gao P,et al. A study of the relationship between digit ratio and breast cancer ［J］.Acta Anthropologica Sinica, 2008,39(4):359-363(in Chinese)陆宏，霍正浩，高平,等.指长比与乳腺癌的相关性研究［J］. 人类学学报，2008,39(4):359-363.

[1]	YANG Meng-yi NIU Shi-bo ZHANG Jing DANG Jie MA Zhan-bing LU Hong HUO Zheng-hao. Association between index finger and ring finger length ratios and polymorphism of homeobox A11 gene locus among Ningxia college students [J]. Acta Anatomica Sinica, 2024, 55(1): 62-66.
[2]	BAI He TENG Ye FENG Lei MENG Hai-wei1 TANG Yu-chun LIU Shu-wei. 3D hippocampal segmentation based on spatial and frequency domain features adaptive fusion and inter-class boundary region enhancement [J]. Acta Anatomica Sinica, 2024, 55(1): 73-81.
[3]	YANG Yang SHI Jun LI Kun MA Yuan ZHANG Shao-jie HOU Er-fei WANG Chao-qun CHEN Jie WANG Xing LI Zhi-jun. Finite element analysis of cervical intervertebral discs after removing different ranges of uncinate processes [J]. Acta Anatomica Sinica, 2024, 55(1): 88-97.
[4]	YAN Yang-yang GUO Kai SUN Zhi-hong . Purinergic ligand-gated ion channel 7 receptor-mediated cognitive impairment in Parkinson’s disease rats [J]. Acta Anatomica Sinica, 2023, 54(5): 531-537.
[5]	HE Ke-ke LI Yuan-di WEN Ting-hao ZHU Jie GAO Jie HU Rong HAN Feng SU Min . Erythrocyte membrane-associated protein inhibiting Th17 cell differentiation via IL-6/STAT3/ROR-γt signaling pathway in experimental autoimmune encephalomyelitis mice encephalomyelitis mice [J]. Acta Anatomica Sinica, 2023, 54(5): 538-545.
[6]	NIU Shi-bo YANG Meng-yi XU Yu DANG Jie MA Zhan-bing HUO Zheng-hao LU Hong . Digit ratio in men with schizophrenia [J]. Acta Anatomica Sinica, 2023, 54(4): 473-476.
[7]	ZHONG Hua WANG Ying FAN Ying-lei REN Hai-long PEMA Dor-ji TONG Qing-hua. Linear measurement of digital pelvic of normal Tibetan nationality female in Lhasa [J]. Acta Anatomica Sinica, 2023, 54(4): 460-464.
[8]	YANG Chen WANG Lu-fei QIAO Hui ZHU Hai-ge WEN Shao-qing ZHANG Hang TAN Jing-ze. Dental non-metric traits of Han and Zhuang people [J]. Acta Anatomica Sinica, 2023, 54(3): 357-367.
[9]	LI Fan MA Zhan-bing ZHANG Jing YANG Meng-yi WANG Yuan MA Qian LU Hong HUO Zheng-hao DANG Jie . Association between hydroxysteroid dehydrogenases gene family single-nucleotide polymorphisms and digit ratio [J]. Acta Anatomica Sinica, 2023, 54(2): 208-215.
[10]	OUYANG Si-wei WANG Yu-tang MA Bin FAN Jie HAI Xiang-jun. Association between the serum adiponectin levels and body composition in perimenopausal and postmenopausal women [J]. Acta Anatomica Sinica, 2023, 54(1): 113-116.
[11]	. Physical characteristics of Xibe adults in Liaoning Province [J]. Acta Anatomica Sinica, 2022, 53(6): 808-814.
[12]	MENG Fan-di GUAN Ying-jun ZHAO Zhen-han CHEN Yan-chun LIU Jin-meng WANG Xue-mei ZHANG Hao-yun ZHOU Feng-hua . Expression of protein tyrosine kinase 7 and receptor tyrosine kinase-like orphan receptor 2 in the brainstem of amyotrophic lateral sclerosis transgenic mice with hSOD1-G93A mutation [J]. Acta Anatomica Sinica, 2022, 53(6): 689-697.
[13]	ZHAO Xian LI Yong-lan YU Hui-xin . Skinfold thickness of adults of Dong people in Guizhou Province [J]. Acta Anatomica Sinica, 2022, 53(5): 644-648.
[14]	LU Jiu-zheng QIAO Hui SUN Chang TAN Jing-ze. Comparison of head and face measurement traits in Chinese Han, Li, Uygur and Tibetan population [J]. Acta Anatomica Sinica, 2022, 53(4): 526-533.
[15]	LI Qiang LI Xin MAIERDANJIANG Mohe-taer ALIMIRE Aier-ken MEIHERIGULI Wujimaimai-ti MAHERE Tuerhong MAIREMUGULI Kuer-ban ZHANG Wen-qian WEN You-feng. Phenotypic characteristics of head and face of Tajik adults in Aketao [J]. Acta Anatomica Sinica, 2022, 53(3): 360-366.