Discordance of aldehyde dehydrogenase 1 and estrogen Receptor expression between primary and metastatic focuses of breast cancer

doi:10.3969/j.issn.0529-1356.2013.02.015

Abstract

Abstract:

Objective To analyze the difference of aldehyde dehydrogenase 1(ALDH1) and estrogen receptor (ER) expression between primary and corresponding metastatic focuses of breast cancer. Methods A total of 87 female patients diagnosed with metastatic breast cancer were included in this study. Immunohistochemistry (IHC) was used to detect the expression of ALDH1 and ER between primary and metastatic sites. Integrated absorbance (IA) of stained sections was measured by Image-Pro Plus 6.0 (IPP 6.0)，and then the statistical analysis was done. Results The incidences of ALDH1 and ER expression among the primary tumor were 28.7%(25 cases) and 56.3% (49 cases), while ascending to 43.7% and declined to 32.2% in corresponding metastatic breast cancer, which were statistically significant respectively (P <0.05 and P <0.01). Statistical analysis results of IA showed that ALDH1 expression in metastatic focuses was obviously higher than that in the corresponding primary tumor, while ER expression was significantly lower. Conclusion The frequencies of ALDH1 positive expression and ER negative expression were more frequently observed in metastatic focuses than in primary breast cancer.

Key words: Breast cancer , Metastasis , Stem cell , Aldehyde dehydrogenase 1 , Estrogen receptor , Immunohistochemistry , Human

SHAO Jun PAN Cui-ping WANG Ming-wei WU Xin-hong MA Biao* . Discordance of aldehyde dehydrogenase 1 and estrogen Receptor expression between primary and metastatic focuses of breast cancer[J]. AAS, 2013, 44(2 ): 224-228.

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