Transforming growth factor-β superfamily signaling and its role in mouse early development

doi:10.3969/j.issn.0529-1356.2013.05.026

Abstract

Abstract:

Transforming growth factor-beta (TGF-β) superfamily signaling has been a hot spot in recent years. TGF-β superfamily ligands bind to their receptors which activate SMADs. The SMAD proteins form a complex in the cytoplasm, which enters the nucleus through the nuclear pore complex, regulating the expression of specific genes. TGF-β superfamity signaling has a lot of functions relating to fibrosis, tumorigenesis and immunoregulation. TGF-β superfamily signaling plays a key role in the early development of mice. In this review, the characteristics of TGF-β superfamily signaling pathway are discussed. We focus on how this signaling influences mouse early embryonic development.

Key words: TGF-&beta, superfamily, Signal transduction, Mouse early embryonic development, Polarization, Mouse

GUO Hao XU Jian*. Transforming growth factor-β superfamily signaling and its role in mouse early development[J]. AAS, 2013, 44(5 ): 722-728.

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