Correlation between D6S296, D8S264 gene polymorphism and schizophrenia of Han/ Zhuang people in Guangxi

doi:10.3969/j.issn.0529-1356.2014.02.027

Abstract

Abstract:

Objective To investigate relationship between D6S296, D8S264 gene polymorphism and schizophrenia of Han, Zhuang people in Guangxi as well as its relevant difference. Methods Han patients (46 cases) with schizophrenia and their immediate family members of the health (49 cases), Zhuang patients with schizophrenia (45 cases) and the health (48 cases) were selected as the research object in Brain Hospital of Guangxi,with healthy families as normal control group. To extract the whole blood DNA and use PCR for DNA amplification, the PCR products with ABI3730XL gene analyzer automatically detect, and statistical genetics method were analyzed. Results D6S296/D8S264 of Han, Zhuang normal control group, each allele frequency distribution were accord with Hardy-Weinberg genetic law of balance (P>0.05). The comparison of Han, Zhuang group of patients with schizophrenia, 264 bp of D6S296 allele frequencies were 2.2% and 18.9% (2/17) respectively, with statistically significant difference (χ ²=13.60, P<0.01);129 bp of D8S264 allele frequency were 18.5% / 8.0% (17/7) respectively, and the difference was statistically significant (χ ²=4.31, P<0.05), and distribution of other allele frequency in each group had no statistical significance (P> 0.05). Conclusion Schizophrenia of Han, Zhuang population in Guangxi may have nothing to do with D6S296, D8S264 polymorphism.

ZHU Sha-sha LI Song-feng*. Correlation between D6S296, D8S264 gene polymorphism and schizophrenia of Han/ Zhuang people in Guangxi[J]. AAS, 2014, (2): 286-290.

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