Progress in the studies of neural stem cell differentiation

doi:10.3969/j.issn.0529-1356.2014.01.027

Abstract

Abstract:

Neural stem cells (NSCs) exist widely in human and mammalian central nervous system. NSCs are multipotent stem cells and have the ability of self-renewal. They can generate neurons, astrocytes and oligodendrocytes. Since Reynold et al firstly isolated NSCs from the corpus striatum of mice, great progress as in this field has been made. However, the number of NSCs in central nervous system (CNS) is relatively small. And as NSCs transplanted into animal brain they mainly differentiate into glial cells and form cicatrix tissue, which restricts the repair of CNS. These factors affect the applications of NSCs in clinical medicine. So how to achieve the directed differentiation is a crucial tissue in this field. The research progress is reviewed in this paper.

Key words: Neural stem cell, Differentiation, Mechanism

XING Hua-jie LI Meng-tao SONG Qing BAI Yun*. Progress in the studies of neural stem cell differentiation[J]. AAS, 2014, 45(1): 140-144.

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