Transcription factor cAMP response element binding protein mediates tumor metastasis and the related molecular mechanism

doi:10.16098/j.issn.0529-1356.2015.01.025

Abstract

Abstract:

Objective Tumor metastasis is a precise and complex process, the mechanism includes cytoskeleton rearrangement, epithelial-mesenchymal transition (EMT) occurance and microRNAs (miRNAs) regulation. cAMP response element binding protein (CREB), an important transcription factor in eukaryotic cell, controls the cytoskeleton rearrangement, EMT occurance and miRNAs by its phosphorylation and overexpression. In the present review, we summarized the research achievements of recent years, revealed the mechanism of CREB-mediated metastasis and put forward the speculation. It is helpful of CREB as a therapeutic target for the prevention and treatment of tumors.

Key words: cAMP reponse element binding protein, Cytoskeleton, Epithelial-mesenchymal transition, MicroRNAs, Tumor metastasis

ZHUANG Hai-hui WANG Xue WANG Ping*. Transcription factor cAMP response element binding protein mediates tumor metastasis and the related molecular mechanism[J]. AAS, 2015, 46(1): 138-143.

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