Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases

doi:10.16098/j.issn.0529-1356.2018.02.022

Abstract

Abstract:

The growth arrest and DNA damage inducible 45 alpha (GADD45α) is a stress-inducible protein. Variety of stress can induce the expression of growth arrest and DNA damage inducible 45alpha(Gadd45α) gene. Gadd45α has been found to be abundantly expressed in various liver diseases, and be closely related to the development and prognosis of liver cancer, liver fibrosis and fatty liver. GADD45α protein plays an important role in regulating cell cycle, maintaining genome stability, and inducing apoptosis by interacting with other proteins. This review summarizes the progress of liver regeneration and GADD45α, and could lay a foundation for further understanding of the mechanism of liver regeneration and liver diseases, and for the treatment and prevention of liver diseases.

Key words: Liver regeneration, Growth arrest and DNA damage inducible 45α, Repair of DNA damage, Cell proliferation

YANG Xian-guang LI Shuai-hong HE Chun-cui XIA Cong ZHU Lin ZHAO Wei-ming XU Cun-shuan. Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases[J]. Acta Anatomica Sinica, 2018, 49(2): 268-272.

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