Protective effect of astragalus polysaccharides in model rats of doxorubicin induced cardiac injury

doi:10.3969/j.issn.0529-1356.2013.05.020

Abstract

Abstract:

Objective To determine the protective effect of astragalus polysaccharides (APS) in doxorubicin induced heart faiure（HF）. Methods Thirty male Sprague-Dawly rats were randomly divided into three groups: control group, HF group and APS group. APS group received APS ［3g/(kg〖DK〗·d］for 14 days. HF group and APS group received doxorubicin 10.4mg/kg every 2 days for 4 times. Ventricular remodeling,apoptosis, and antioxidant indices were examined after the last intragastric administration. Results APS protected heart from myocardial fibrosis, myofibrils dissolve and broke, and mitochondria swelling. Evident cardiac damage induced by doxorubicin was revealed by hemodynamic changes and TUNEL staining compared to the control group. APS treatment caused significant attenuation of malonyldialdehyde（MDA）and Bax express. Superoxide dismutase (SOD) activity and Bcl-2 expression were significantly increased by APS in heart failure rats. Conclusion APS decreases doxorubicin-induced cardiotoxicity.

Key words: Astragalus polysaccharides, Doxorubicin, Heart failure, Antioxidation, 　TUNEL staining｜　Rat

CLC Number:

Q813.11

GUAN Peng XU Bing-yuan LI Ya-qing GUO Qiu-hong WANG Na*. Protective effect of astragalus polysaccharides in model rats of doxorubicin induced cardiac injury[J]. AAS, 2013, 44(5 ): 685-688.

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