Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (6): 814-818.doi: 10.16098/j.issn.0529-1356.2018.06.020

• Anthropology • Previous Articles     Next Articles

Serum leptin and polymorphism of leptin receptor gene Gln223Arg of Qinghai patients with pregnancy-induced hypertension syndrome

ZHUANG Wen-ting1 ZHAO De-xiong2 WANG Xiang-lin1 LI Hong-rong3 LI Chang-xing1 LI Fu-xin1 KONG De-xia4 LI Jian-hua 1*   

  1. 1.Department of Human Anatomy, Basic Medicine, Medical College of Qinghai University, Xining 810001,China; 2.Department of Obstetrics, Qinghai Red Cross Hospital, Xining 810001,China; 3.Department of Surgery, Gansu Wuwei Tumor Hospital, Gansu Wuwei 733000,China; 4.Department of Obstetrics, the Second People’s Hospital of Xining City, Xining 810001,China
  • Received:2018-05-08 Revised:2018-06-10 Online:2018-12-06 Published:2019-02-28
  • Contact: LI Jian-hua E-mail:1184666039@qq.com
  • Supported by:
    Association of Polymorphism Gene Polymorphisms with Pregnancy-induced Hypertension Disorders in Qinghai Tibetan and Han Women

Abstract:

Objective To investigate the relationship between polymorphism of leptin receptor(LEPR) gene Gln223Arg (rs1137101) and pregnancyinduced hypertension syndrome. Methods The study consisted of 107 patients of pregnancy-induced hypertension syndrome (PIH) subjects, 116 normal pregnancy subjects were studied to detect their sera level of leptin by ELISA. The LEPR Gln223Arg genotype was detected by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Results The PIH group sera leptin level was higher than control group(P<0.05).The frequences of GG,GA,AA genotype of LEPR Gln223Arg in PIH group were 49.5%,43.9% and 6.5%, in control group were 63.8%,32.8% and 3.4%. There was difference in frequency distribution of LEPR genotype between PIH group and control group. The frequency of A gene in PIH group was higher than the control group(χ2=4.60,P<0.05,OR=0.62,95% CI=0.40-0.96).Conclusion The A allele of LEPR Gln223Arg might be a genetic marker and a latent risk factor for PIH recurrence.

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