Objective To investigate the relationship between single nucleotide polymorphism (SNP) FokⅠ（rs2228570/rs10735810）of vitamin D receptor (VDR) gene and hypertensive disorder complicating pregnancy (HDCP) in Han nationality women of Qinghai province.   Methods A total of 137 Han nationality HDCP subjects (HDCP group) and 146 Han nationality normal pregnant subjects (control group) were selected from Qinghai province. The FokⅠ polymorphism typing in HCDP group and control group was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The mutation was confirmed by sequencing. SPSS 19.0 statistical software was used to test whether there were significant differences between two groups in general clinical data, genotype and allele frequency distribution.   Results The frequency of FF Ff ff genotype of FokⅠ in HDCP group and control group were 51.82%, 37.96%, 10.22% and 34.93%, 43.15%, 21.92% respectively (χ²=11.099, P<0.05, the distribution of genotype was different significantly between the two groups), the frequency of FF genotype in HDCP group (OR=2.004, 95%CI=1.243-3.231) was higher than that in control group; The frequency distribution of alleles F and f of FokⅠ was significantly different between HDCP group and control group (χ²=12.454, P<0.001), F allele frequency in HDCP group (OR=1.253, 95%CI=1.105-1.421) was higher than that in control group.   Conclusion The FokⅠ polymorphism of VDR gene is significantly correlated with hypertensive disorder complicating pregnancy of Han nationality in Qinghai. The F allele may be the susceptibility gene of HDCP, the FF genotype may be the susceptibility genotype of HDCP.

Qinghai province, Hypertensive disorder complicating pregnancy, Vitamin-D receptor, Genetic polymorphism, FokⅠ site, Polymerase chain reactionrestriction fragment length polymorphism, Pregnant woman