Objective  To explore the distribution situation of microRNA(miR) -30 gene single-nucleotide sites rs1192037A/T polymorphisms in Guangxi Zhuang population and compare its distribution differences with other populations and to analyze level of common blood lipid indexes in genotypes.    Methods  SNPscan was used to detect rs1192037A/T locus genotyping in 236 volunteers of Zhuang nationality in Guangxi. The genotypes and allele frequencies of rs1192037A/T locus genotyping in different genders and groups were analyzed. The levels of common blood lipids in the subjects were detected by roche automatic biochemical apparatus.    Results  Three genotypes of AA, AT and TT were found in rs1192037 A/T with the frequency distribution of 11.0%, 38.6% and 50.4%, respectively.  No significant differences in genotypes and alleles frequencies of rs1192037 A/T  between different genders in Guangxi Zhuang population were observed (P>0.05). However,there were significant differences in the genotype and allele frequency of miR-30 gene rs1192037 A/T in Guangxi Zhuang population compared with those of Europeans, Japanese, Africans, Mexicans and Indians published by HapMap  (P<0.05), and there were not significant difference in genotypes and allele frequencies in population of HCB and JTP (P>0.05). There were significant differences in the levels of TG among the 3 genotypes of rs1192037 A/T, and the TG levels of AT and TT genotypes were significantly higher than AA genotypes.    Conclusion  There are different degrees of rs1192037 A/T polymorphisms of miR-30 gene among Guangxi population and other ethnic populations and other regions. The polymorphism of rs1192037 A/T is related to the level of TG.