骨髓间充质干细胞成脂成骨平衡调控研究进展

doi:10.16098/j.issn.0529-1356.2019.03.023

摘要/Abstract

摘要：

骨质疏松症（OP）是一种全身性的骨代谢疾病，主要表现为骨量减少、骨质脆性增加、骨骼微结构退化。随着对骨质疏松症发病机制的深入研究，骨髓间充质干细胞（BMSCs）分化失衡（成骨分化减少，成脂分化增多）是引发骨质疏松症的关键。我们总结了BMSCs成脂成骨分化相关的信号通路，充分理解这些信号通路，有利于更好的阐明骨质疏松症的发病机制，为临床医生有效地治疗骨质疏松症提供帮助。

关键词: 平衡调控, 骨髓间充质干细胞, 成骨分化, 成脂分化, 信号通路

Abstract:

Osteoporosis (OP), a systemic bone metabolism disease, mainly manifested in the decrease of bone mass, the increase of bone fragility and the microstructure degeneration of the bone. Along with the in-depth research of the pathogenesis of osteoporosis, the imbalance differentiation of bone marrow mesenchymal stem cell (BMSCs) (Osteogenic differentiation decrease and adipogenic differentiation increase) is the main reason that causes osteoporosis. In this paper, we summarize the signal pathways of osteogenic differentiation and adipogenic differentiation of BMSCs. Better understand these signal pathways is conducive to elucidate and treat osteoporosis.

Key words: Balance regulation, Bone marrow mesenchymal stem cell, Osteogenic differentiation, Adipogenic differentiation, Signal pathway

占秀文杨磊郑美蓉汪鑫平许晓源. 骨髓间充质干细胞成脂成骨平衡调控研究进展[J]. 解剖学报, 2019, 50(3): 400-404.

ZHAN Xiu-wen YANG Lei ZHENG Mei-rong WANG Xin-ping XU Xiao-yuan. Research progress on the balance regulation of osteogenic differentiation and adipogenic differentiation in bone marrow mesenchymal stem cell[J]. Acta Anatomica Sinica, 2019, 50(3): 400-404.

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