关键词: 胆总管, 几何形态, 顺应性, 生物力学, 异种移植, 人, 猪

Abstract: Objective To explore the relationship of the geometric morphology and compliance of the common bile duct (CBD) between human and pig and to provide theoretical basis for pigtohuman liver xenotransplantation. Methods The CBDs of 5 adult corpses and 50 Hubei white pigs aged between 3-12 months were obtained. The pressurediameter relationship of the CBD was measured in the biomechanical testing system for soft tissues; the compliance was calculated then. The materials were extracted through transverse frozen sections, and then stained with HE. The diameter and wall thickness of CBD were measured by computer image analysis system. Results The diameter and the wall thickness of CBD of pigs aged between 36 months were significantly shorter or thinner respectively than that of adult human (P<0.01), while the results of pigs aged between 7-10 months are similar to that of the adult human (P>0.05). The compliance of the CBD of pigs aged between 3-6 months and 11-12 months was significantly smaller than that of adult human (P<0.01), while the results of pigs aged between 7-10 months were similar to that of the adult human (P>0.05).Conclusion The geometric morphology and compliance of the CBD of pigs aged between 7-10 months are similar to that of the adult human, suggesting that it is possible for the liver of pigs aged between 7-10 months to be used as the donor for liver xenotransplantati

Key words: Common bile duct, Geometrical morphology, Compliance, Biomechanics, Xenotransplantation, Human, Pig