多发性硬化和视神经脊髓炎的脑灰质结构分析

doi:10.16098/j.issn.0529-1356.2024.01.003

解剖学报 ›› 2024, Vol. 55 ›› Issue (1): 17-24.doi: 10.16098/j.issn.0529-1356.2024.01.003

多发性硬化和视神经脊髓炎的脑灰质结构分析

刘晓丽¹ 许琳² 吴爱雪¹ 闻彩云³ 李如画¹ 吴安婷¹ 陈黛茜⁴ 陈成春^1*

1. 温州医科大学基础医学院解剖学教研室，浙江温州 325000; 2. 荆门市第一人民医院检验科，湖北荆门 448001; 3. 温州医科大学附属第一医院放射科，浙江温州 325000; 4. 温州医科大学附属第一医院中医科，浙江温州 325000

收稿日期:2022-12-12 修回日期:2023-02-14 出版日期:2024-02-06 发布日期:2024-02-06
通讯作者: 陈成春 E-mail:liusw@sdu.edu.cn

Analysis of cerebral gray matter structure in multiple sclerosis and neuromyelitis optica

LIU Xiao-li¹ XU Lin² WU Ai-xue¹ WEN Cai-yun ³ LI Ru-hua¹ WU An-ting¹ CHEN Dai-qian⁴ CHEN Cheng-chun^1*

1. Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Zhejiang Wenzhou 325000, China; 2. Laboratory Jingmen First People’s hospital, Hubei Jingmen 448001, China; 3. Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325000, China; 4. Department of Traditional Chinese Medicine, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325000, China

Received:2022-12-12 Revised:2023-02-14 Online:2024-02-06 Published:2024-02-06
Contact: CHEN Cheng-Chun E-mail:liusw@sdu.edu.cn

摘要/Abstract

摘要：

目的利用基于体素的形态学测量(VBM)和基于皮层的脑形态学测量(SBM)方法对多发性硬化（MS）和视神经脊髓炎（NMO）患者脑灰质体积及皮层厚度进行比较分析，探讨这两种疾病的脑灰质结构变化的差异。方法对21例MS患者，16例NMO患者以及19例健康对照者行磁共振常规序列扫描，基于Matlab2014a平台的统计参数工具SPM12以及SPM12下的小工具CAT12，对VBM和SBM方法处理的数据进行分析。结果 MS组与正常对照(NC)组相比，经高斯随机场(GRF)校正后，MS组在左侧枕上回、左侧楔叶、左侧距状皮质、左侧楔前叶、左侧中央后回、左侧中央旁小叶、右侧楔叶、左侧额中回、左侧额上回和左侧额内侧回灰质体积显著性减少(P＜0.05)；经族系错误(FWE)法校正后，MS组在左侧中央旁小叶、左侧额上回和左侧楔前叶皮层厚度显著性减少(P＜0.05)。NMO组与NC组相比，经GRF校正后，NMO组在左侧中央后回、左侧中央前回、左侧顶下小叶、右侧中央前回和右侧额中回灰质体积显著性增加(P＜0.05)；NMO组在左侧枕中回、左侧枕上回、左侧颞下回、右侧枕中回、左侧额上回眶部、右侧中扣带回、左侧前扣带回、右侧角回和左侧楔前叶灰质体积显著性减少(P＜0.05)；经FWE校正后，NMO组与NC组相比皮层厚度没有显著性差异的脑区。MS组与NMO组相比，经GRF校正后，MS组在右侧梭状回和右侧额中回灰质体积显著性增加(P＜0.05)；MS组在左侧丘脑、左侧苍白球、左侧中央前回、左侧额中回、左侧颞中回、右侧苍白球、左侧顶下小叶和右侧顶上小叶灰质体积显著性减少(P＜0.05)；经FWE校正后，MS组在左侧顶下小叶、左侧顶上小叶、左侧缘上回、左侧中央旁小叶、左侧额上回和左侧楔前叶皮层厚度显著性减少(P＜0.05)。结论 MS患者脑灰质结构萎缩主要累及左侧顶叶区域，NMO患者对于脑灰质结构的改变不敏感。MS患者与NMO患者差异显著性的脑区主要位于脑深部灰质相关核团。

关键词: 多发性硬化, 视神经脊髓炎, 脑结构, 基于体素的形态学分析, 基于皮层的脑形态学分析, 人

Abstract:

Objective The volume and cortical thickness of gray matter in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO) were compared and analyzed by voxel based morphometry (VBM) and surface-based morphometry (SBM), and the differences in the structural changes of gray matter in the two diseases were discussed. Methods A total of 21 MS patients, 16 NMO patients and 19 healthy controls were scanned by routine MRI sequence. The data were processed and analyzed by VBM and SBM method based on the statistical parameter tool SPM12 of Matlab2014a platform and the small tool CAT12 under SPM12. Results Compared with the normal control group (NC), after Gaussian random field (GRF) correction, the gray matter volume in MS group was significantly reduced in left superior occipital, left cuneus, left calcarine, left precuneus, left postcentral, left central paracentral lobule, right cuneus, left middle frontal, left superior frontal and left superior medial frontal (P<0.05). After family wise error (FWE) correction, the thickness of left paracentral, left superiorfrontal and left precuneus cortex in MS group was significantly reduced (P<0.05). Compared with the NC group, after GRF correction, the gray matter volume in the left postcentral, left precentral, left inferior parietal, right precentral and right middle frontal in NMO group was significantly increased (P<0.05). In NMO group, the volume of gray matter in left middle occipital, left superior occipital, left inferior temporal, right middle occipital, left superior frontal orbital, right middle cingulum, left anterior cingulum, right angular and left precuneus were significantly decreased (P<0.05). Brain regions showed no significant differences in cortical thickness between NMO groups after FWE correction. Compared with the NMO group, after GRF correction, the gray matter volume in the right fusiform and right middle frontal in MS group was increased significantly(P<0.05). In MS group, the gray matter volume of left thalamus, left pallidum, left precentral, left middle frontal, left middle temporal, right pallidum, left inferior parietal and right superior parietal were significantly decreased (P<0.05). After FWE correction, the thickness of left inferiorparietal, left superiorparietal, left supramarginal, left paracentral, left superiorfrontal and left precuneus cortex in MS group decreased significantly (P<0.05). Conclusion The atrophy of brain gray matter structure in MS patients mainly involves the left parietal region, while NMO patients are not sensitive to the change of brain gray matter structure. The significant difference in brain gray matter volume between MS patients and NMO patients is mainly located in the deep cerebral nucleus mass.

Key words:

Multiple sclerosis, Neuromyelitis optica, Structure of brain, Morphological analysis based on voxel, Cerebral morphological analysis, Human

中图分类号:

R455.2

刘晓丽许琳吴爱雪闻彩云李如画吴安婷陈黛茜陈成春.

多发性硬化和视神经脊髓炎的脑灰质结构分析 [J]. 解剖学报, 2024, 55(1): 17-24.

LIU Xiao-li XU Lin WU Ai-xue WEN Cai-yun LI Ru-hua WU An-ting CHEN Dai-qian CHEN Cheng-chun.

Analysis of cerebral gray matter structure in multiple sclerosis and neuromyelitis optica [J]. Acta Anatomica Sinica, 2024, 55(1): 17-24.

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多发性硬化和视神经脊髓炎的脑灰质结构分析

Analysis of cerebral gray matter structure in multiple sclerosis and neuromyelitis optica

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