›› 2009, Vol. 40 ›› Issue (2): 246-249.doi: 10.3969/j.issn.0529-1356.2009.02. 015
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乐嫣 ;朱浩; 王文进; 丁文龙*
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关键词: P>高糖, 施万细胞, Bcl-2, Bax, TUNEL, 免疫印迹法, 大鼠/P>
Abstract: Objective To study the effects and possible mechanism of highglucose on rat Schwann cells growth and apoptosis EM>in vitro/EM>. Methods Schwann cells were cultured with different concentrations of glucose for 72 hours. MTT assays were used to detect the activities of SCs. Apoptosis was observed by TUNEL assay. The expressions of Bcl-2 and Bax protein were evaluated by Western blotting assay. Results In high-glucose (60mmol/L，90mmol/L) group，the activity of SCs was decreased and the rate of apoptosis was increased. The expression level of Bcl-2 in SCs was decreased while Bax expression level was increased in high glucose culture. Conclusion High glucose inhibits the growth of SCs and increases the cell apoptosis，which is possibly caused by decreasin
Key words: High-glucose, Schwann cell, Bcl-2, Bax, TUNEL, Western Blotting, Rat
中图分类号:
R322.85
乐嫣;朱浩;王文进;丁文龙. 高糖对培养大鼠施万细胞生长、凋亡的影响及其机制探讨[J]. , 2009, 40(2): 246-249.
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链接本文: https://jpxb.bjmu.edu.cn/CN/10.3969/j.issn.0529-1356.2009.02. 015
https://jpxb.bjmu.edu.cn/CN/Y2009/V40/I2/246
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