解剖学报

›› 2009, Vol. 40 ›› Issue (2): 299-302.doi: 10.3969/j.issn.0529-1356.2009.02.026

• 论著 • 上一篇    下一篇

兔下颌骨牵张成骨中HIF-1α和EM>c-fos/EM>的表达及其相关性

赵翚１;谢志坚2*;何剑锋2 ;葛巍立2 ;林坚1 ;胡济安2   

  1. 1.温州市第三人民医院口腔颌面外科，浙江 温州 325000; 2.浙江大学附属口腔医院颌面外科，杭州 310006
  • 收稿日期:2008-07-17 修回日期:2008-09-18 出版日期:2009-04-06
  • 通讯作者: 谢志坚

Expressions of HIF-1α，EM>c-fos/EM> and their relationships in mandibular distraction osteogenesis in rabbits

  1. P>1.Department of Oral and Maxillofacial Surgery, the Third People’s Hospital of Wenzhou City,Zhejiang Wenzhou 325000,China;2.Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital,College of Medicine, Zhejiang University,Hangzhou 310006,China/P>
  • Received:2008-07-17 Revised:2008-09-18 Online:2009-04-06
  • Contact: XIE Zhi-jian

关键词: HIF-1α, c-fos, 下颌骨, 牵张成骨, 免疫组织化学, 兔

Abstract: P>Objective To investigate the expressions of HIF-1α, c-fos and their relationships in mandibular distraction osteogenesis in rabbits. Methods To establish an animal model of mandibular distraction osteogenesis with 25 healthy adult rabbits.The expressions of HIF-1α and EM>c-fos/EM> were detected by ultrasensitive SP immunohistochemical methods. Results Immunohistochemical studies showed that the HIF-1α was expressed strongly in distraction zone at the 8th days after distraction. One week after consolidation, the EM>c/EM>-EM>fos/EM> was expressed strongly in the distraction zone at the 4 th day, 8th days after distraction, and 1 week after consolidation.Both apparently expressed apparently higher than those in the distraction zone of at the third and fifth week after consolidation. HIF-1α and EM>c-fos/EM> were mainly expressed in fibroblasts, osteoblasts and osteocytes. Conclusion In mandibular distraction osteogenesis of rabbits, there is a marked relati

Key words: HIF-1α, EM>c-fos/EM>, Mandibular, Distraction osteogenesis, Immunohistochemistry, Rabbit

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