解剖学报

解剖学报 ›› 2014, Vol. ›› Issue (2): 171-175.doi: 10.3969/j.issn.0529-1356.2014.02.005

• 神经生物学 • 上一篇    下一篇

卵泡刺激素受体在山羊颈胸神经节的分布

金秀芳 王志豪 范洁 徐永平* 陈文东 郭晓   

  1. 西北农林科技大学动物医学学院基础解剖学研究室， 陕西 杨凌 712100
  • 收稿日期:2013-03-26 修回日期:2013-05-06 出版日期:2014-04-06 发布日期:2014-04-06
  • 通讯作者: 徐永平 E-mail:xuyp717@yahoo.com.cn
  • 基金资助:

    国家自然科学基金重点资助项目

Distribution characteristics of follicle-stimulating hormone receptor in the cervicothoracic ganglion of goat

JIN Xiu-fang WANG Zhi-hao FAN Jie XU Yong-ping* CHEN Wen-dong GUO Xiao   

  1. Basic Anatomy Laboratory,College of Veterinary Medicine, Northwest A&F University, Shanxi Yangling 712100, China
  • Received:2013-03-26 Revised:2013-05-06 Online:2014-04-06 Published:2014-04-06
  • Contact: XU Yong-ping E-mail:xuyp717@yahoo.com.cn

摘要：

目的 探讨卵泡刺激素（FSH）是否影响心肺功能活动的自主神经调节。方法 取雄性和雌性成年山羊的颈胸神经节各５对，经免疫组织化学ＳＰ法染色后，观察FSH受体在山羊颈胸神经节的分布特点。 结果 在颈胸神经节内，FSH受体免疫阳性产物主要存在于神经元的细胞质和细胞膜，为强阳性或中等阳性染色，而细胞核呈空泡状，不着色。此外，在神经节内的支持细胞、过路纤维、施万细胞以及血管内皮细胞中FSH受体呈弱阳性染色，有少量分布。图像分析表明，该神经节内神经元胞体的FSH受体相对表达量极显著高于其他非神经元胞体结构（P＜0.01）。结论 颈胸神经节中神经元细胞是FSH作用的主要靶细胞，提示FSH可能通过影响该神经节的神经元活动，从而影响其发出的交感节后神经而调节心肺功能活动。

Abstract:

Objective To investigate whether follicle stimulating hormone (FSH) affects autonomic regulation of cardiopulmonary function. Methods Five pairs of cervicothoracic ganglion were taken from mature female and male gosts. The distribution of follicle stimulating hormone receptor (FSHR) in the cervicothoracic ganglion of the goat was observed after immunohisto-chemical SP staining. Results FSHR immunoreactive substances mainly distributed in neurons’ cytoplasm and membrane, but not in the nucleus. There was some expression of FSHR in surrounding supporting cells, passing fibers,Schwan cells and vascular endothelial cells. Image analysis showed that the relative expression of immunoreactive product FSHR was significantly higher than that of other nonneural structures(P＜0.01). Conclusion These results suggest that the neurons in cerricothoracic ganglion are the main target cells of FSH in goats and FSH is likely to affect neurons of the cervicothoracic ganglion and then further to regulate cardiopulmonary function activities via the postganglionic sympathetic nerve.