解剖学报

›› 2012, Vol. 43 ›› Issue (3): 412-416.doi: 10.3969/j.issn.0529-1356.2012.03.022

• 组织学胚胎学发育生物学 • 上一篇    下一篇

甲醛对机体整体内源性代谢产物的影响

徐浩1; 崔立然 2* ; 张玲2   

  1. 1.齐齐哈尔医学院解剖学教研室，黑龙江 齐齐哈尔 161006; 2.齐齐哈尔医学院第一附属医院药学研究室，黑龙江 齐齐哈尔 161041
  • 收稿日期:2011-08-16 修回日期:2011-11-18 出版日期:2012-06-06
  • 通讯作者: 崔立然

Effects of formaldehyde on the endogenous metabolism in the body

  1. 1.Department of Anatomy, Qiqihar Medical University, Heilongjiang Qiqihar 161006, China; 2.Drug Research Room, the First Affiliated Hospital of Qiqihar Medical University, Heilongjiang Qiqihar 161041, China
  • Received:2011-08-16 Revised:2011-11-18 Online:2012-06-06
  • Contact: CUI Li-ran

关键词: 甲醛, 内源性代谢产物, 生物标志物, 超高效液相色谱与串联四级杆飞行时间质谱检测, 人

Abstract: Objective To investigate effects of formaldehyde on endogenous metabolites of urine. Methods The urinary samples of the formaldehyde contact group and control group were analyzed by UPLC –Q-TOF/MS, combined with principal component analysis(PCA). The overall disease pattern of the metabolic network was established based on metabolic profiles in different groups. Results The different trajectory of urine was visually noted from metabolic profiles between 2 groups. Metabolomics appeared to be suitable for toxicity studies of formaldehyde, and a biomarker structure was identified. Conclusion The science connotation of the toxicity of formaldehyde may be elucidated by Metabonomics, according to metabolites variance in certain disease

Key words: Formaldehyde, Endogenous metabolism, Biomarker, Ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry, Human

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