低雌激素引发潮热的外周机制

doi:10.16098/j.issn.0529-1356.2016.05.024

摘要/Abstract

摘要：

近年来，潮热已成为困扰因各种原因导致低雌激素状态的妇女工作和生活的主要因素之一，严重影响其生活质量。目前国际公认潮热的发生是中枢体温调节热中性带变窄，体温调节系统紊乱所致。既往主要是研究雌激素降低后，引起体温调节中枢功能异常，从而诱发潮热的机制，而较少关注其中枢整合后传出通路的外周体温调节作用方式的变化情况。我们从外周体温调节的3种基本方式，即交感神经系统调节、躯体神经系统调节和肾上腺激素与甲状腺激素分泌调节，对低雌激素状态下的潮热的外周体温调节机制进行综述。

关键词: 低雌激素, 潮热, 体温调节, 神经调节, 体液调节, 人

Abstract:

In recent years, hot flashes have become one of the main factors which bother work and life of the women with low estrogen for various reasons. It greatly influences their quality of life. The narrow of the hypothalamic temperature set point has been internationally recognized as a mechanism of hot flashes. Because of this, the regulation of body temperature is losing its balance. Previous studies pay more attention to the mechanism in the relationship between the reduction of estrogen and disorder in central nervous system, which lead to hot flash. However, it focuses less on its efferent pathway of thermoregulation. In this article, we review the mechanism of thermoregulation by peripheral nervous system in hot flashes of menopause from three main ways which are the regulation of sympathetic nervous system, the regulation of somatic nervous system and the endocrine activity of adrenal hormone and thyroid hormone.

Key words: Low estrogen, Hot flash, Low estrogen, Hot flash, Thermoregulation, Neuroregulation, Humoral regulation, Human

姜海张晶王文娟王珂秦丽华白文佩. 低雌激素引发潮热的外周机制[J]. 解剖学报, 2016, 47(5): 709-713.

JIANG Hai ZHANG Jing WANG Wen-juan WANG Ke QIN Li-hua BAI Wen-pei. Mechanism of peripheral regulation of temperature in hot flushes of low estrogen[J]. Acta Anatomica Sinica, 2016, 47(5): 709-713.

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