microRNAs在肝再生中的作用研究进展

doi:10.16098/j.issn.0529-1356.2017.02.020

摘要/Abstract

摘要：

目的 microRNAs是一类非编码蛋白的小RNA分子，通过与靶基因mRNA 3’端的非编码区（3’UTRS）结合而在转录后水平调控基因表达，调节细胞增殖、分化、代谢、凋亡、器官发育等生物学过程。肝脏有很强的再生能力，是研究再生的重要材料。因此，我们在文中总结了microRNAs对肝再生调节作用的研究进展。

关键词: microRNA, 肝再生, 肝细胞增殖

Abstract:

microRNAs (miRNAs) are a group of endogenous, small, noncoding RNA molecules which can regulate gene expression at posttranscriptional level by binding to the 3’ untranslated regions (3’UTRs) of their target mRNAs. It has been reported that miRNAs regulated a variety of biological processes, including cell proliferation, differentiation, apoptosis, metabolic process，organ development，etc. Liver as one of the organs with extraordinary regenerative abilities, is considered to be an important material for the research of regeneration mechanism. This paper summarized the research advance of the role of microRNAs in liver regeneration.

Key words: microRNAs, Liver regeneration, Hepatocyte proliferation

臧夏炎耿小芳张春艳徐存拴. microRNAs在肝再生中的作用研究进展[J]. 解剖学报, 2017, 48(2): 230-235.

ZANG Xia-yan GENG Xiao-fang ZHANG Chun-yan XU Cun-shuan. Role of microRNAs in liver regeneration[J]. Acta Anatomica Sinica, 2017, 48(2): 230-235.

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