氧化应激在组织再生中的作用的研究进展

doi:10.16098/j.issn.0529-1356.2018.03.024

摘要/Abstract

摘要：

活性氧在细胞增殖、分化、凋亡中发挥着重要作用，氧化应激是机体内活性氧的生成和清除不平衡所引起的一种机体应激反应，低浓度的活性氧对细胞的生长和分化是有利的，可作为信号分子诱导细胞的增殖。研究表明，动物的肝、肌肉、心肌、神经、肢和尾等在受到损伤后，均具有一定的自身修复和再生能力，组织再生与人类疾病的发生及治疗密切相关，在这些过程中均有氧化应激的参与。我们概述了氧化应激在不同组织器官再生过程中的作用及其机制，为揭示组织再生机制和人类疾病的治疗提供理论依据。

关键词: 氧化应激, 活性氧, 细胞增殖, 再生

Abstract:

Reactive oxygen species play a critical role in cell proliferation, differentiation and apoptosis, oxidative stress, as a stress response, resultsed from the imbalance between the production and removal of reactive oxygen species within body. Low concentration of reactive oxygen species is favorable for cell growth and differentiation, and could be regarded as an essential signal to induce cell proliferation. It has been shown that the damaged animal organs, such as liver, muscle, heart, nerves, limb and tail, have ability to repair and regenerate. Tissue regeneration is closely associated with human disease and treatment, and oxidative stress is involved in these processes. This paper summarizes the role of oxidative stress and its mechanism in the process of tissue regeneration, which would provide the basis for the mechanism of regeneration and the treatment of human diseases especially regenerative medicine in the future.

Key words: Oxidative stress, Reactive oxygen species, Cell proliferation, Regeneration

郭建林闫培硕徐存拴. 氧化应激在组织再生中的作用的研究进展[J]. 解剖学报, 2018, 49(3): 412-418.

GUO Jian-lin1 YAN Pei-shuo XU Cun-shuan . Research progress of 0xidative stress in tissue regeneration[J]. Acta Anatomica Sinica, 2018, 49(3): 412-418.

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