视网膜Müller细胞重编程研究进展

doi:10.16098/j.issn.0529-1356.2023.04.016

摘要/Abstract

摘要：

视网膜退行性疾病导致的失明严重影响人类健康。哺乳动物视网膜损伤后无法自我修复，而斑马鱼的视网膜具有较强的再生能力，能再生所有类型的视网膜神经元并恢复视觉。斑马鱼的视网膜再生依赖于一种神经胶质细胞——Müller细胞。斑马鱼视网膜损伤后Müller细胞重编程并增殖产生祖细胞，后者进一步分化为新生的视网膜神经元。近年来，基于Müller细胞的视网膜再生研究取得了许多重要进展。我们就斑马鱼视网膜再生的机制和哺乳动物Müller细胞重编程的研究进展做一综述。

关键词: 视网膜, 再生, 重编程, Müller细胞, 斑马鱼

Abstract:

Blinding eye diseases caused by retinal degeneration have a detrimental effect on human health. Mammalian retina exhibits very limited capacity for self-repair after degenerative disease or injury. In contrast, zebrafish retina possesses a robust regenerative response that regenerates all types of retinal neurons and restores vision. Retina regeneration in zebrafish depends on a type of glia cells called Müller glia. Following retinal injury, zebrafish Müller glia undergo a reprogramming process and proliferate into multipotent progenitor cells that further differentiate into newborn retinal neurons. In recent years, significant progress has been made in the field of Müller glia-based retina regeneration. Here we summarize the mechanisms governing zebrafish retina regeneration and the recent advances in mammalian Müller glia reprogramming.

Key words: Retina, Regeneration, Reprogramming, Müller glia, Zebrafish

中图分类号:

Q189

张小丽张书强徐绘 . 视网膜Müller细胞重编程研究进展[J]. 解剖学报, 2023, 54(4): 484-489.

ZHANG Xiao-li ZHANG Shu-qiang XU Hui . Research progress in the reprogramming of retinal Müller glia cells[J]. Acta Anatomica Sinica, 2023, 54(4): 484-489.

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