›› 2007, Vol. 38 ›› Issue (1): 23-26.doi:
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姚治芳;李正莉*;童逸龄;朱晓琴;卫向红
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关键词: 癫痫, 白细胞介素-2, 白细胞介素2受体, N甲基D, 天门冬氨酸型受体1, 雌激素受体, 激光共焦显微镜, 免疫组织化学, 大鼠
Abstract: Objective To explore the correlation between the epilepsy induced by interleukin-2 (IL-2) and changes of NMDA receptor(NMDAR) and estrogen receptor(ER). Methods Methods of immunohistochemistry, double fluorescent immunohistochemistry and laser scanning confocal microscopy were applied to study the expression changes of NMDAR-1 and ER and the coexistence of NMDAR/ER and NMDAR/IL-2R in the brains of rats with epilepsy induced by IL-2 or rats treated with immunosuppressants prior to the inducement. Results The rats displayed an obvious seizure after the lateral ventricle was injected with IL-2. The expressions of NMDAR-1 and ER were markedly increased and there was a significant difference in immunoreactive average absorbance (A) in cerebral cortex and hippocampus between IL-2 group and the control group. However, with the pretreatment of IL-2 inhibitors, such as cyclosporine or glucocorticoid, the epileptic behaviors of rats with IL-2 were inhibited and the immunoreaction of NMDAR-1 and ER was obviously decreased compared with IL-2 group (P<0.05). It was also found that NMDAR/IL-2R or NMDAR/ER coexisted largely in cerebral cortex and hippocampus. Conclusion IL-2 could induce epilepsy. There exist cooperation and interaction between NMDAR-1, IL-2R and ER in epileptogenic mechanisms.
Key words: Epilepsy, Interleukin-2, IL-2R, NMDAR-1, ER, Laser scanning confocal microscopy, Immunohistochemistry, Ra
中图分类号:
R742.1
姚治芳;李正莉;童逸龄;朱晓琴;卫向红. NMDA受体1和雌激素受体在白细胞介素-2致痫大鼠脑内的表达变化和共存[J]. , 2007, 38(1): 23-26.
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https://jpxb.bjmu.edu.cn/CN/Y2007/V38/I1/23
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