解剖学报

解剖学报 ›› 2019, Vol. 50 ›› Issue (6): 800-804.doi: 10．16098/j.issn.0529－1356．2019．06．018

• 解剖学 • 上一篇    下一篇

基于血流剪切力的变化探讨颈椎旋转手法对兔颈动脉重度粥样硬化血管的影响

关钛元1,2 祁冀3 刘洋1,2 徐燕笑1,2 武凯3 张少群3 陈奕历3 张磊1,2,3*   

  1. 1.西南医科大学附属中医医院骨伤科，四川 泸州　646000； 2.泸州市院士工作站，四川 泸州　646000；3.南方医科大学中医药学院针灸推拿教研室，广州　510515
  • 收稿日期:2018-12-18 修回日期:2019-03-25 出版日期:2019-12-06 发布日期:2019-12-06
  • 通讯作者: 张磊 E-mail:307501597@qq.com
  • 基金资助:
    国家自然科学基金资助项目;泸州市院士工作站在建项目

Effects of cervical rotatory manipulation on severe rabbit carotid atherosclerosis in flow sheer stress

GUAN Taiyuan 1,2  QI Ji3 LIU Yang 1,2 XU Yanxiao 1,2 WU Kai3 ZHANG Shao-qun3 CHEN Yili3 ZHANG Lei 1,2,3*   

  1. 1.Department of Orthopedics,Affiliation Traditional Chinese Medicine Hospital of Southwest Medical University， Sichuan Luzhou　646000, China; 2.Academician Workstation in Luzhou, Sichuan Luzhou　646000, China; 3.Department of Acupunctare and Massage, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou　510515, China
  • Received:2018-12-18 Revised:2019-03-25 Online:2019-12-06 Published:2019-12-06
  • Contact: ZHANG Lei E-mail:307501597@qq.com

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摘要：

目的　探讨颈椎旋转手法（CRM）对兔重度粥样硬化颈动脉的血流剪切力的影响，以期为手法的安全性提供参考。方法　40只健康新西兰兔随机分为手法组（n=15）、模型组（n=15）和对照组（n=10），采用球囊拉伤联合高脂饮食饲养的方法对手法组和模型组兔进行颈动脉粥样硬化（CAS）模型制作。模型制作后手法组予以CRM干预2周，通过彩超检测及血液黏滞度检测计算血流剪切力。以单因素方差分析的方法比较3组间血流剪切力的差异。 结果　手法组和模型组兔颈动脉血流剪切力分别为（11.732±6.679、18.215±8.581）dynes/cm2，显著低于对照组（23．488±5．312）dynes/cm2（P<0.05）；且手法组血流剪切力低于模型组（P<0.05）。 　结论　CRM可使兔重度粥样硬化的颈动脉血流剪切力降低，进而可能导致粥样硬化斑块进一步发展，甚至出现斑块稳定性下降或脱落。

Abstract:

Objective　To investigate the effects of cervical rotatory manipulation (CRM) on severe carotid atherosclerosis of rabbits in hemodynamics. 　Methods　Totally 40 New Zealand rabbits were divided randomly into 3 groups, including the manipulation group, the model group and the control group. Left carotid atherosclerotic plaques models were developed in the rabbits of manipulation group and model group. Then, the manipulation group was treated with CRM lasting for 2 weeks; meanwhile no intervention was given on rabbits in the model group and control group. At the end of manipulation, flow sheer stress (FSS) was calculated with velocity and viscosity of blood. One way ANOVA and LSR-t test　were performed to explore the significance. 　Results　FSS of left carotid artery in rabbit decreased significantly in the manipulation group and the model group, in comparison with the control group. Moreover, FSS in the manipulation group was lower than that in the model group. 　Conclusion　FSS of severe atherosclerotic carotid artery in rabbit may become decreased following with CRM.