MiR-429生物学功能的研究进展

doi:10.16098/j.issn.0529-1356.2022.02.019

摘要/Abstract

摘要：

微小RNA（miRNA）是一类长度在22个核苷酸左右的内源性非编码单链RNA。这类RNA在细胞中发挥着重要的生物学功能，其中miR-429经大量研究证实，可以通过对不同靶基因的表达进行调控从而发挥抑制肿瘤发生和进展的重要作用，同时也能够在细胞分化和神经性疾病中发挥作用。我们对miR-429及其下游靶基因在细胞增殖、凋亡、迁移和侵袭中发挥的作用进行了概述。

关键词: 微小RNA-429, 生物学功能, 细胞增殖, 细胞迁移, 细胞侵袭

Abstract:

MicroRNAs (miRNAs, miR) are endogenous non-coding single-stranded RNAs with a length of about 22 nucleotides. These RNAs play an important biological function within cells, among which, miR-429 has been proved to play an important role in inhibiting tumor development and tumor progression as well as in cell differentiation and neurological diseases by regulating the expression of different target genes. In this paper, the role of miR-429 and its downstream targeted genes in cell proliferation, apoptosis, migration and invasion is summarized.

Key words: MicroRNA-429, Biological function, Cell proliferation, Cell migration, Cell invasion

中图分类号:

Q752

郭建林王雪晴徐存拴. MiR-429生物学功能的研究进展[J]. 解剖学报, 2022, 53(2): 266-272.

GUO Jian-lin WANG Xue-qing XU Cun-shuan. Advances in biological functions of miR-429[J]. Acta Anatomica Sinica, 2022, 53(2): 266-272.

参考文献

［1］ Wang YH, Jiang XX. Research progress in biological function of microRNA-129［J］. Military Medical Sciences, 2018, 42(05): 384-388.(in Chinese)

王玉涵，江小霞. MicroRNA-129生物学功能的研究进展［J］. 军事医学，2018，42(05)：384-388.

［2］ Sun X, Li Z, Chen Y. The potential prognostic value of microRNA-429 for human gliomas［J］. Ann Clin Lab Sci, 2016, 46(1): 44-48.

［3］ Yu T, Lu XJ, Li JY, et al. Overexpression of miR-429 impairs intestinal barrier function in diabetic mice by down-regulating occludin expression［J］. Cell Tissue Res, 2016, 366(2): 341-352.

［4］ Xu J, Wu W, Wang J, et al. MiR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7［J］. Oncol Rep, 2017, 37(2): 1052-1058.

［5］ Peng Y, Chen FF, Ge J, et al. MiR-429 inhibits differentiation and promotes proliferation in porcine preadipocytes［J］. Int J Mol Sci, 2016, 17(12): 2047.

［6］ Zhang FX, Dong ZM, Chen GW, et al. Progress of microRNAs in planarian regeneration［J］. Acta Anatomica Sinica, 2020, 51(4): 631-636. (in Chinese)

张芬熙，董自梅，陈广文，等. 微小RNAs在涡虫再生中的研究进展［J］. 解剖学报，2020，51(4)：631-636.

［7］ Yu G, Jia BL, Cheng YS, et al. MicroRNA-429 sensitizes pancreatic cancer cells to gemcitabine through regulation of PDCD4［J］. Am J Transl Res, 2017, 9(11): 5048-5055.

［8］ Cheng ZH, Li ZSN, Ma K, et al. Long non-coding RNA XIST promotes glioma tumorigenicity and angiogenesis by acting as a molecular sponge of miR-429［J］. J Cancer, 2017, 8(19): 4106-4116.

［9］ Zhu Q, Hu J, Wang L, et al. Inhibition of microRNA-429 in the renal medulla increased salt sensitivity of blood pressure in Sprague Dawley rats［J］. J Hypertens Suppl, 2017, 35(9): 1872-1880.

［10］ Altuvia Y, Landgraf P, Lithwick G, et al. Clustering and conservation patterns of human microRNAs［J］. Nucleic Acids Res, 2005, 33(8): 2697-2706.

［11］ Wu JM, Liu MY, Xu HL, et al. Prediction of hsa-miR-429 target gene and bioinformatics analysis［J］. Progress of Anatomical Sciences, 2019, 25(3): 312-315.(in Chinese)

吴嘉美，刘梦瑶，许何丽，等. hsa-miR-429的靶基因预测及功能分析［J］. 解剖科学进展，2019，25(3)：312-315.

［12］ Li D, Wang H, Song H, et al. The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells［J］. Oncotarget, 2017, 8(49): 85276-85289.

［13］ Meng X, Joosse SA, Muller V, et al. Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients［J］. Br J Cancer, 2015, 113(9): 1358-1366.

［14］ Lin Z, Wang X, Fewell C, et al. Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of epstein-barr virus reactivation by the miR-200 family member miR-429［J］. J Virol, 2010, 84(15): 7892-7897.

［15］ Wang C, Ju H, Shen CY, et al. MiR-429 mediates δ-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP［J］. Int J Clin Exp Med, 2015, 8(9): 15648-15656.

［16］ Huang XY, Yao JG, Huang HD, et al. MicroRNA-429 modulates hepatocellular carcinoma prognosis and tumorigenesis［J］. Gastroenterol Res Pract, 2013, 2013: 804128.

［17］ Wu CL, Ho JY, Hung SH, et al. MiR-429 expression in bladder cancer and its correlation with tumor behavior and clinical outcome［J］. Kaohsiung J Med Sci, 2018, 34(6): 335-340.

［18］ Wu CL, Ho JY, Chou SC, et al. MiR-429 reverses epithelial-mesenchymal transition by restoring E-cadherin expression in bladder cancer［J］. Oncotarget, 2016, 7(18): 26593-26603.

［19］ Boland CR, Shin SK, Goel A. Promoter methylation in the genesis of gastrointestinal cancer［J］. Yonsei Med J, 2009, 50(3): 309-321.

［20］ Huang WJ, Wu L, Hou L, et al. Detection of the expression of miRNA-429 and its methylation status in breast cancer［J］. Journal of Qingdao University(Medical Sciences), 2018,54(1):26-29.(in Chinese)

黄文剑，吴琍，侯琳，等. 乳癌组织miRNA-429基因表达及甲基化检测［J］. 青岛大学学报(医学版)，2018，54(1)：26-29.

［21］ Wang Y, Qin T, Hu W, et al. Genome-wide methylation patterns in androgen-independent prostate cancer cells: a comprehensive analysis combining medip-bisulfite, RNA, and microRNA sequencing data［J］. Genes (Basel), 2018, 9(1):32.

［22］ Tang J, Li L, Huang W, et al. MiR-429 increases the metastatic capability of HCC via regulating classic wnt pathway rather than epithelial-mesenchymal transition［J］. Cancer Lett, 2015, 364(1): 33-43.

［23］ Lize M, Pilarski S, Dobbelstein M. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis［J］. Cell Death Differ, 2010, 17(3): 452-458.

［24］ Chen L, Xue Y, Zheng J, et al. MiR-429 regulated by endothelial monocyte activating polypeptide-Ⅱ (EMAP-Ⅱ) influences blood-tumor barrier permeability by inhibiting the expressions of ZO-1, Occludin and Claudin-5［J］. Front Mol Neurosci, 2018, 11: 35.

［25］ Zhang L, Yang P,Liu Q. KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling［J］. Neoplasma, 2020, 67(3): 519-527.

［26］ Chen FT, Hou L, Han QX, et al. Effect of microRNA-429 on proliferation and migration of breast cancer cells and preliminary identification of itstargetgenes［J］. Journal of Qingdao University(Medical Sciences), 2019, 55(3): 325-329.(in Chinese)

陈凤婷，侯琳，韩清昕，等. miR-429对乳癌细胞增殖和迁移影响及其靶基因初步鉴定［J］. 青岛大学学报(医学版)，2019，55(3)：325-329.

［27］ Lv GS, Li L, Chen X, et al. MiR-429 regulates inflammatory infiltration, proliferative ability and differentiation of hepatocellular carcinoma［J］. Academic Journal of Second Military Medical University, 2015, 36(5): 465-471.(in Chinese)

吕桂帅，李亮，陈昕，等. MiR-429调节肝细胞癌炎性微环境、分化及增殖［J］. 第二军医大学学报，2015，36(5)：465-471.

［28］ Lei W, Liu YE, Zheng Y, et al. MiR-429 inhibits oral squamous cell carcinoma growth by targeting ZEB1［J］. Med Sci Monit, 2015, 21: 383-389.

［29］ Chen DQ, Li YC, Li YF, et al. Tumor suppressive microRNA-429 regulates cellular function by targeting VEGF in clear cell renal cell carcinoma［J］. Mol Med Rep, 2016, 13(2): 1361-1366.

［30］ Deng Y, Luan F, Zeng L, et al. MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1［J］. EXCLI J, 2017, 16: 618-627.

［31］ Zou J, Liu L, Wang Q, et al. Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1［J］. Am J Transl Res, 2017, 9(3): 1357-1368.

［32］ Wang D, Zheng J, Liu X, et al. Knockdown of USF1 inhibits the vasculogenic mimicry of glioma cells via stimulating SNHG16/miR-212-3p and linc00667/miR-429 axis［J］. Mol Ther Nucleic Acids, 2019, 14: 465-482.

［33］ Fan JY, Fan YJ, Wang XL, et al. MiR-429 is involved in regulation of NF-kappaBactivity by targeting IKKbeta and suppresses oncogenic activity in cervical cancer cells［J］. FEBS Lett, 2017, 591(1): 118-128.

［34］ Zhang M, Dong BB, Lu M, et al. MiR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells［J］. Onco Targets Ther, 2016, 9: 1123-1133.

［35］ Goeppert B, Ernst C, Baer C, et al. Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma［J］. Epigenetics, 2016, 11(11): 780-790.

［36］ Yang HZh, Tan ZhQ, Wan L, et al. MiR-429 inhibits proliferation and promote apoptosis of human ovarian cancer cells by targeting SOX2［J］. Hainan Medical Journal, 2019, 30(10): 1234-1237.(in Chinese)

杨慧芝，谭志琴，万兰，等. miR-429靶向调控SOX2抑制人卵巢癌细胞增殖与促进凋亡［J］. 海南医学，2019，30(10)：1234-1237.

［37］ Wu L, Liu Y, Guo C, et al. LncRNA OIP5-AS1 promotes the malignancy of pancreatic ductal adenocarcinoma via regulating miR-429/FOXD1/ERK pathway［J］. Cancer Cell Int, 2020, 20: 296.

［38］ Zhang C, Chang C, Gao H, et al. MiR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway［J］. Cell Signal, 2018, 50: 80-89.

［39］ Zhu p, Zhang J, et al. MiR-429 induces gastric carcinoma cell apoptosis through Bcl-2［J］.Cell Physiol Biochem, 2015, 37(4): 1572-1580

［40］ Zhang T, Tian F, Wang J, et al. Atherosclerosis-associated endothelial cell apoptosis by miR-429-mediated down regulation of Bcl-2［J］. Cell Physiol Biochem, 2015, 37(4): 1421-1430.

［41］ Li X, Chen H, Wang S, et al. Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE［J］. Biochem Biophys Res Commun, 2017, 490(4): 1197-1204.

［42］ Ge L, Wang Y, Cao Y, et al. MiR-429 improved the hypoxia tolerance of human amniotic cells by targeting HIF-1alpha［J］. Biotechnol Lett, 2018, 40(11-12): 1477-1486.

［43］ Guo C, Zhao D, Zhang Q, et al. MiR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition［J］. Sci Rep, 2018, 8(1): 2375.

［44］ Samantarrai D, Mallick B. MiR-429 inhibits metastasis by targeting KIAA0101 in soft tissue sarcoma［J］. Exp Cell Res, 2017, 357(1): 33-39.

［45］ Chen H, Xia B, Liu T, et al. KIAA0101, a target gene of miR-429, enhances migration and chemoresistance of epithelial ovarian cancer cells［J］. Cancer Cell Int, 2016, 16: 74.

［46］ Liu D, Song L, Dai Z, et al. MiR-429 suppresses neurotrophin-3 to alleviate perineural invasion of pancreatic cancer［J］. Biochem Biophys Res Commun, 2018, 505(4): 1077-1083.

［47］ Ni J, Yang Y, Liu D, et al. MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1［J］. Oncol Lett, 2017, 13(5): 3845-3849.

［48］ Sun Y, Shen S, Liu X, et al. MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma［J］. Mol Cell Biochem, 2014, 390(1-2): 19-30.

［49］ Sheng N, Zhang L, Yang S. MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase［J］. Exp Ther Med, 2018, 15(2): 1927-1933.

［50］ Wu D, Niu X, Pan H, et al. Tumor-suppressing effects of microRNA-429 in human renal cell carcinoma via the downregulation of Sp1［J］. Oncol Lett, 2016, 12(4): 2906-2911.

［51］ Ye ZB, Ma G, Zhao YH, et al. MiR-429 inhibits migration and invasion of breast cancer cells in vitro［J］. Int J Oncol, 2015, 46(2): 531-538.

［52］ Su Z, Jiang G, Chen J, et al. MicroRNA-429 inhibits cancer cell proliferation and migration by targeting AKT1 in renal cell carcinoma［J］. Mol Clin Oncol, 2020, 12(1): 75-80.

［53］ Huang J, Peng J, Cao G, et al. Hypoxia-induced microRNA-429 promotes differentiation of MC3T3-E1 osteoblastic cells by mediating ZFPM2 expression［J］. Cell Physiol Biochem, 2016, 39(3): 1177-1186.

［54］ Fu S, Zhang J, Zhang S. Knockdown of miR-429 attenuates Aβ-induced neuronal damage by targeting SOX2 and BCL2 in mouse cortical neurons［J］. Neurochem Res, 2018, 43(12): 2240-2251.

［55］ Li C, Niu J, Zhou B, et al. Dexmedetomidine attenuates cisplatin-induced cognitive impairment by modulating miR-429-3p expression in rats［J］. 3 Biotech, 2020, 10(6): 244.

［56］ Sun R, Yu DSh. Inhibitory effect of miR-429 on expressions of ZO-1, Occludin, and Claudin-5 proteins to improve the permeability of blood spinal cord barrier in vitro［J］. Chinese Journal of Reparative and Reconstructive Surgery, 2020, 34(9): 1163-1169.(in Chinese)

孙瑞, 于德水. 抑制miR-429促进ZO-1、Occludin和Claudin-5蛋白表达改善血脊髓屏障通透性的体外实验研究［J］. 中国修复重建外科杂志，2020，34(9)：1163-1169

［57］ Luan YR, Liu LY, Jiao L, et al. Clinical significance of miR-429 and Bmi-1 mRNA expression in diffuse large B-cell lymphoma［J］. Carcinogenesis, Teratogensis & Mutagensis, 2020, 32(3): 177-181.(in Chinese)

栾亦然，刘丽源，皎龙，等. MiR-429及Bmi-1 mRNA在弥漫性大B细胞淋巴瘤中的表达及其临床意义［J］. 癌变·畸变·突变，2020，32(3)：177-181.

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