›› 2009, Vol. 40 ›› Issue (3): 485-490.doi: 10.3969/j.issn.0529-1356.2009.03.028

• 论著 • 上一篇    下一篇

辛伐他汀对颈椎异体骨移植融合过程的影响

杨允1; 张凯宁1; 吴荧光1 ; 张虎1 ; 任延军1 ;邹德波1 ; 张佐伦2 ; 张立平3*    

  1. 1. 山东大学附属千佛山医院骨科,济南 250014;2. 山东省立医院脊柱外科,济南 250016;3. 山东大学医学院解剖学教研室,济南 250012
  • 收稿日期:2008-05-07 修回日期:2008-09-22 出版日期:2009-06-06
  • 通讯作者: 张立平

Effect of simvastatin on the fusion process of cervical intervertebral cortical bone allograft transplantation

  1. 1.Depatment of Orthopedics, Shandong University affiliated Qianfoshan Hospital, Ji’nan 250014, China; 2.Department of Spine Surgery, Shandong Provincial Hospital, Ji’nan 250016, China; 3.Department of Anatomy, School of Medicine, Shandong University, Ji’nan 250012, China
  • Received:2008-05-07 Revised:2008-09-22 Online:2009-06-06
  • Contact: ZHANG Li-ping

关键词: 辛伐他汀, 颈椎, 异体骨皮质, 融合, 组织化学, 大鼠

Abstract: Objective To investigate the effect of simvastatin on fusion process after cortical bone allograft transplantation for anterior cervical intervertebral fusion. Methods Forty--four male Wistar rats,undergone anterior cervical discectomy and fusion with allogenous cortical bone transplantation, were divided into 4 groups: control group, simvastatin group, recombinant human bone morphogenetic protein2(rhBMP-2) group and bland group. The animals of the first 3 groups were sacrificed to obtain cervical spine specimen and performed pathological examination at 2, 4, 8, and 12week intervals. The bone mineral density of cervical vertebral body was also measured. Results The bone mineral density of control group decreased markedly compared with that of blank group. No difference was found among that of the simvastatin, BMP2 and blank groups. Inflammatory fibrous capsule existed for a prolonged period and little endochondral calcification in the soft tissue was observed in control group. In both simvastatin and rhBMP-2 groups, bony fusion between the trabecula and the surface of allograft bone was achieved earlier. But in the rhBMP-2 group, fusion was observed only at the surface of the implant. Invasion of soft tissue and new blood vessels into the core region of the implants were apparent in the simvastatin group. And scattered neonate osteons were found within allograft. Conclusion Simvastatin demonstrated the potency of promotin

Key words: Simvastatin, Cervical spine, Cortical bone allograft, Fusion, Histochemistry, Rat

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