关键词: 宫颈肿瘤, 埃兹蛋白, 金属蛋白酶-2, 金属蛋白酶抑制因子-2, 肿瘤转移, 免疫组织化学

Abstract: Objective To identify their expressions of Ezrin, atrix metalloproteinases2(MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2)in human cervical carcinoma, to clarify their relationships between these expressions and invasion, metastasis of human cervical carcinoma. Methods Ezrin, MMP-2 and TIMP-2 were detected immunohistochemically in 40 cases of squamous cell carcinoma of the uterine cervix, in 20 cases of adenocarcinoma of the uterine cervix, in 29 cases of cervical intraepithelial neoplasia (CIN) and 16 cases of normal cervices. Results Immunohistochemical staining of tumor cells for Ezrin, MMP-2 and TIMP-2 were noted in intracytoplasm. There were significant differences for Ezrin, MMP-2 and TIMP-2 in squamous cell carcinoma and adenocarcinoma of the uterine cervix, CIN and normal cervices respectively (P<0.01). The positive rates of Ezrin and MMP-2 in lymph node metastasis were obviously higher than that in without lymph node metastasis(P<0.01)，but for TIMP-2 it was contrary. The expressions of Ezrin between MMP-2 and TIMP-2 protein were positively correlated in cervical lesions respectively（EM>rSUB>S/SUB>/EM>=0422, EM>P/EM>=0.000; EM>rSUB>S/SUB>/EM>=0294, EM>P/EM>=0.002）. Conclusion The expressions for Ezrin, MMP-2 and TIMP-2 in squamous cell carcinoma and adenocarcinoma of the uterine cervix are higher than that in control group. The overexpressions of three markers possibly play a key role in invasion and lymphnode metastasis of carcinoma of the cervix

Key words: Cervix neoplasms, Ezrin, Matrix metalloproteinase, Tissueinhibitor of metalloprteinase, Neoplasm metastasis, Immunohistochemistry