解剖学报

›› 2010, Vol. 41 ›› Issue (1): 114-118.doi: 10.3969/j.issn.0529-1356.2010.01.022

• 论著 • 上一篇    下一篇

过氧化物酶体增殖因子激活受体γ、环氧合酶-2在子宫内膜癌中的表达及超微结构定位

卞海燕1;李媛媛2;吴洪娟2;刘雨清1*   

  1. 1.潍坊医学院病理学教研室,山东 潍坊;2.形态学实验室，山东 潍坊261042
  • 收稿日期:2008-11-13 修回日期:2009-01-24 出版日期:2010-02-06
  • 通讯作者: 刘雨清

Expression and ultrastructure location of PPAR-γ and COX-2 in endometrial carcinoma

  1. 1.Department of Pathology, Weifang Medical University, Shandong Weifang 261042,China;2.Laboratory of Morphology, Weifang Medical University, Shandong Weifang261042,China1.Department of Pathology, Weifang Medical University, Shandong Weifang261042,China;2.Laboratory of Morphology, Weifang Medical University, Shandong Weifang 261042,China
  • Received:2008-11-13 Revised:2009-01-24 Online:2010-02-06
  • Contact: LIU Yu-qing

关键词: 激活过氧化物酶体增殖因子受体-γ, 环氧合酶-2, 子宫内膜癌, 免疫组织化学, 胶体金免疫电镜技术, 人

Abstract: Objective To investigate the development and prognosis of peroxisome proliferators-activated receptor-γ(PPAR-γ) and cyclooxygenase-2(COX-2) in endometrial carcinoma. Methods The electron microscopic immunohistochemical technique was used to observe the ultrastructure location of COX-2 protein labeled by colloidal gold in the endometrial carcinoma. Results 1.There were negative immunohistochemical staining signals of PPAR-γ in both the normal endometrium and hyperplasia endometrium, whereas, was positive staining in the endometrial carcinoma; 2.The intensities of the COX-2 immunohistochemical staining were significantly statistical difference among the normal endometrium, the hyperplasia endometriu and the endometrial carcinoma(EM>P/EM><0.01); 3. The COX-2 labelled by colloidal gold granules was observed in the endoplasmic reticulum, nuclear membrane and nuclei in the endometrial carcinoma. Conclusion Both PPAR-γ and the COX-2 might play an important role in the development

Key words: PPAR-γ, COX-2, Endometrial carcinoma, Immunohistochemistry, Colloidal gold immunoelectron microscopy technique, Human

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