解剖学报

›› 2011, Vol. 42 ›› Issue (2): 226-231.doi: 10.3969/j.issn.0529-1356.2011.02.017

• 论著 • 上一篇    下一篇

罗格列酮对OLETF大鼠肺组织TGF-β1/Smad信号转导途径的影响

赵伟1;姜丽娟1;朱梦瑜2;刘佳1; 张雅静1;陈晓琴1;张宏1*   

  1. 1．天津医科大学代谢病医院肥胖代谢科，卫生部激素与发育重点实验室;2. 天津医科大学基础医学院免疫教研室，天津300070
  • 收稿日期:2010-07-12 修回日期:2010-08-14 出版日期:2011-04-06
  • 通讯作者: 张宏

Effects of rosiglitazone treatment on TGF-β1/Smad signaling pathways in Otsuka Long-Evans Tokushima Fatty rat lungs

  1. 1. Department of Obesity & Metabolic, Metabolic Diseases Hospital of Tianjin Medical University, Key Laboratory of Hormones and Development, Ministry of Public Health; 2. Department of Immunology, Elementary Medical College of Tianjin Medical University, Tianjin300070, China
  • Received:2010-07-12 Revised:2010-08-14 Online:2011-04-06
  • Contact: ZHANG Hong

关键词: 糖尿病, 肺, 罗格列酮, 转化生长因子-β1, Smad, 免疫组织化学, 大鼠

Abstract: Objective To approach the effects of rosiglitazone treatment on transforming growth factor-β1/Smad(TGF-β1/Smad) signaling pathways in Otsuka Long-Evans Tokushima Fatty(OLETF) rats. Methods Experimental rats were divided into three groups: OLETF group, rosiglitazone-treated group(OLETF/L group) and Long Evans Tokushima Otsuka rats (LETO group) as control, 8 rats in each group. The expression of TGF-β1, Smad2, Smad3, Smad7, fibronectin(FN), and collagen type Ⅲ in rat lungs were examined by immunohistochemistry. Results The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ increased in OLETF rat lungs than those of LETO rats(EM>P/EM><0.01), while the expression of Smad7 decreased in OLETF group(EM>P/EM><0.01). The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ decreased in OLETF/L group than those of the OLETF group(EM>P/EM><0.01), and the expression of Smad7 increased in OLETF/L group(EM>P/EM><0.01). Conclusion

Key words: Diabetes mellitus, Lung, Rosiglitazone, Transforming growth factor-β1, Smad, Immunohistochemistry, Rat

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